Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 694419..695200 Replicon chromosome
Accession NZ_CP060672
Organism Salmonella enterica strain 190729_8

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag H9Q85_RS03185 Protein ID WP_000626100.1
Coordinates 694709..695200 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag H9Q85_RS03180 Protein ID WP_001110452.1
Coordinates 694419..694712 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q85_RS03145 (690466) 690466..691371 + 906 WP_001268200.1 YjiK family protein -
H9Q85_RS03150 (691665) 691665..691796 - 132 Protein_600 hypothetical protein -
H9Q85_RS03155 (691908) 691908..692156 - 249 Protein_601 Ig-like domain-containing protein -
H9Q85_RS03160 (692155) 692155..692463 + 309 WP_072095651.1 ABC transporter ATP-binding protein -
H9Q85_RS03165 (692456) 692456..692743 - 288 WP_001541332.1 transcriptional regulator RtsB -
H9Q85_RS03170 (692740) 692740..693615 - 876 WP_000921676.1 AraC family transcriptional regulator -
H9Q85_RS03175 (693881) 693881..694102 - 222 WP_001576552.1 hypothetical protein -
H9Q85_RS03180 (694419) 694419..694712 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
H9Q85_RS03185 (694709) 694709..695200 + 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
H9Q85_RS03190 (695448) 695448..696200 - 753 WP_000842433.1 non-specific acid phosphatase -
H9Q85_RS03195 (696300) 696300..696377 - 78 Protein_609 porin family protein -
H9Q85_RS03200 (696757) 696757..696831 + 75 Protein_610 helix-turn-helix domain-containing protein -
H9Q85_RS03210 (697102) 697102..697677 - 576 WP_001188509.1 transcriptional regulator -
H9Q85_RS03215 (697714) 697714..699417 - 1704 WP_000068885.1 protein-disulfide reductase DsbD -
H9Q85_RS03220 (699393) 699393..699740 - 348 WP_000887832.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T170623 WP_000626100.1 NZ_CP060672:694709-695200 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T170623 NZ_CP077661:1030542-1030844 [Enterobacter cloacae complex sp. ECL112]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTTGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT170623 WP_001110452.1 NZ_CP060672:694419-694712 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT170623 NZ_CP077661:1030851-1031138 [Enterobacter cloacae complex sp. ECL112]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCTGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References