Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 75332..76955 Replicon plasmid unnamed
Accession NZ_CP060671
Organism Salmonella enterica strain 190807_1

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag H9Q86_RS23245 Protein ID WP_000088046.1
Coordinates 75332..76657 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag H9Q86_RS23250 Protein ID WP_024136327.1
Coordinates 76662..76955 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q86_RS23215 72002..72301 - 300 WP_001572440.1 hypothetical protein -
H9Q86_RS23220 72356..72592 - 237 Protein_91 type I restriction-modification system subunit M N-terminal domain-containing protein -
H9Q86_RS23225 73046..73471 - 426 WP_001043843.1 hypothetical protein -
H9Q86_RS23230 73725..74540 - 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
H9Q86_RS23235 74553..74963 - 411 WP_000985911.1 hypothetical protein -
H9Q86_RS23240 75065..75271 - 207 WP_000134171.1 hypothetical protein -
H9Q86_RS23245 75332..76657 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
H9Q86_RS23250 76662..76955 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
H9Q86_RS23255 77587..77979 - 393 WP_000341066.1 hypothetical protein -
H9Q86_RS23260 78352..78693 + 342 WP_001151575.1 hypothetical protein -
H9Q86_RS23265 78785..78976 + 192 WP_000398480.1 hypothetical protein -
H9Q86_RS23270 79026..79307 + 282 WP_000077926.1 hypothetical protein -
H9Q86_RS23275 79462..80166 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
H9Q86_RS23280 80220..80447 - 228 Protein_103 IS4 family transposase -
H9Q86_RS23285 80590..81450 + 861 WP_000557454.1 aminoglycoside N-acetyltransferase AAC(3)-IId -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(A) / blaCTX-M-15 / aac(3)-IId rck / pefD / pefC / pefA / pefB / fdeC / spvC / spvB 1..109445 109445


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T170620 WP_000088046.1 NZ_CP060671:c76657-75332 [Salmonella enterica]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T170620 NZ_CP077660:4525989-4526276 [Enterobacter cloacae complex sp. ECL78]
ATGCATAAATTAACACCCTACGATCCAGCCAACGCACTGGTGGATGACGAGGAAATCGCTGTGTTTATGGCTGATGCATT
AGAGACGGGTGACTCAGCGTACATTGCTAAAGCGCTGGGCGTCATCGCCCGAGCGAAAGGGATGTCGACCATTTCCCAGC
AAACGGGCCTGTCACGAGAACAACTGTATCGATCATTCAGTGATAAGGGGAACCCAACGCTCAAAACCACGCTGGCGGTC
ATGAAAGCATTGGGCCTTGGGTTAACAATCAAACCCTCTGGGGATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT170620 WP_024136327.1 NZ_CP060671:c76955-76662 [Salmonella enterica]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT170620 NZ_CP077660:4525680-4525982 [Enterobacter cloacae complex sp. ECL78]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAATTTAAAGGACAGGCGGGCAAAGACGATTATCGC
TTCCCGCCTCTTTAGGCTGGCAAATGGCTTAGCGGGCGACATTAGACCCGTGGGGGAAGGTATCAGTGAACTGAGGATCC
ACTTGGGCCCGGGCTACAGAGTCTATTTTAAGGACCAGGGCAATTGCATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References