Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4430808..4431589 Replicon chromosome
Accession NZ_CP060670
Organism Salmonella enterica strain 190807_1

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag H9Q86_RS21460 Protein ID WP_000626100.1
Coordinates 4431098..4431589 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag H9Q86_RS21455 Protein ID WP_001110452.1
Coordinates 4430808..4431101 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q86_RS21420 (4426855) 4426855..4427760 + 906 WP_001268200.1 YjiK family protein -
H9Q86_RS21425 (4428054) 4428054..4428185 - 132 Protein_4171 hypothetical protein -
H9Q86_RS21430 (4428297) 4428297..4428545 - 249 Protein_4172 Ig-like domain-containing protein -
H9Q86_RS21435 (4428544) 4428544..4428852 + 309 WP_072095651.1 ABC transporter ATP-binding protein -
H9Q86_RS21440 (4428845) 4428845..4429132 - 288 WP_001541332.1 transcriptional regulator RtsB -
H9Q86_RS21445 (4429129) 4429129..4430004 - 876 WP_000921676.1 AraC family transcriptional regulator -
H9Q86_RS21450 (4430270) 4430270..4430491 - 222 WP_001576552.1 hypothetical protein -
H9Q86_RS21455 (4430808) 4430808..4431101 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
H9Q86_RS21460 (4431098) 4431098..4431589 + 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
H9Q86_RS21465 (4431837) 4431837..4432589 - 753 WP_000842433.1 non-specific acid phosphatase -
H9Q86_RS21470 (4432689) 4432689..4432766 - 78 Protein_4180 porin family protein -
H9Q86_RS21475 (4433146) 4433146..4433220 + 75 Protein_4181 helix-turn-helix domain-containing protein -
H9Q86_RS21485 (4433491) 4433491..4434066 - 576 WP_001188509.1 transcriptional regulator -
H9Q86_RS21490 (4434103) 4434103..4435806 - 1704 WP_000068885.1 protein-disulfide reductase DsbD -
H9Q86_RS21495 (4435782) 4435782..4436129 - 348 WP_000887832.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T170615 WP_000626100.1 NZ_CP060670:4431098-4431589 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T170615 NZ_CP077660:2550135-2550620 [Enterobacter cloacae complex sp. ECL78]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACCTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGGAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCAGTTGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT170615 WP_001110452.1 NZ_CP060670:4430808-4431101 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT170615 NZ_CP077660:2549881-2550147 [Enterobacter cloacae complex sp. ECL78]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCGGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References