Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3105426..3106086 Replicon chromosome
Accession NZ_CP060670
Organism Salmonella enterica strain 190807_1

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag H9Q86_RS15210 Protein ID WP_000244756.1
Coordinates 3105426..3105839 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag H9Q86_RS15215 Protein ID WP_000351186.1
Coordinates 3105820..3106086 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q86_RS15190 (3101367) 3101367..3103100 - 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -
H9Q86_RS15195 (3103106) 3103106..3103819 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H9Q86_RS15200 (3103843) 3103843..3104739 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
H9Q86_RS15205 (3104852) 3104852..3105373 + 522 WP_001055885.1 flavodoxin FldB -
H9Q86_RS15210 (3105426) 3105426..3105839 - 414 WP_000244756.1 protein YgfX Toxin
H9Q86_RS15215 (3105820) 3105820..3106086 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
H9Q86_RS15220 (3106336) 3106336..3107316 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
H9Q86_RS15225 (3107432) 3107432..3108091 - 660 WP_000250289.1 hemolysin III family protein -
H9Q86_RS15230 (3108255) 3108255..3108566 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
H9Q86_RS15235 (3108724) 3108724..3110157 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T170609 WP_000244756.1 NZ_CP060670:c3105839-3105426 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T170609 NZ_CP077659:c3379506-3379096 [Enterobacter cloacae complex sp. ECL72]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT170609 WP_000351186.1 NZ_CP060670:c3106086-3105820 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT170609 NZ_CP077659:c3379753-3379487 [Enterobacter cloacae complex sp. ECL72]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References