Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 17481..18006 | Replicon | plasmid unnamed |
| Accession | NZ_CP060669 | ||
| Organism | Salmonella enterica strain 190819_2 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | I3W3D5 |
| Locus tag | H9Q87_RS22855 | Protein ID | WP_001159863.1 |
| Coordinates | 17701..18006 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | M7S5D0 |
| Locus tag | H9Q87_RS22850 | Protein ID | WP_000813641.1 |
| Coordinates | 17481..17699 (+) | Length | 73 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9Q87_RS22820 (H9Q87_22695) | 13095..13481 | + | 387 | WP_000751876.1 | YgiW/YdeI family stress tolerance OB fold protein | - |
| H9Q87_RS22825 (H9Q87_22700) | 13534..13653 | + | 120 | Protein_17 | recombinase | - |
| H9Q87_RS22830 (H9Q87_22705) | 14022..15011 | - | 990 | WP_000461382.1 | RepB family plasmid replication initiator protein | - |
| H9Q87_RS22835 (H9Q87_22710) | 15505..15800 | - | 296 | Protein_19 | cytoplasmic protein | - |
| H9Q87_RS22840 (H9Q87_22715) | 15812..16240 | + | 429 | Protein_20 | hypothetical protein | - |
| H9Q87_RS22845 (H9Q87_22720) | 16284..16805 | - | 522 | WP_077681952.1 | hypothetical protein | - |
| H9Q87_RS22850 (H9Q87_22725) | 17481..17699 | + | 219 | WP_000813641.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
| H9Q87_RS22855 (H9Q87_22730) | 17701..18006 | + | 306 | WP_001159863.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
| H9Q87_RS22860 (H9Q87_22735) | 18008..18298 | + | 291 | WP_001266176.1 | hypothetical protein | - |
| H9Q87_RS22865 (H9Q87_22740) | 18295..18816 | + | 522 | WP_000198608.1 | hypothetical protein | - |
| H9Q87_RS22870 (H9Q87_22745) | 18851..19633 | + | 783 | WP_000082169.1 | site-specific integrase | - |
| H9Q87_RS22875 (H9Q87_22750) | 19642..20355 | + | 714 | WP_000545756.1 | EAL domain-containing protein | - |
| H9Q87_RS22880 (H9Q87_22755) | 20380..20868 | + | 489 | WP_001075507.1 | CaiF/GrlA family transcriptional regulator | - |
| H9Q87_RS22885 (H9Q87_22760) | 20862..21347 | + | 486 | WP_000905606.1 | membrane protein | - |
| H9Q87_RS22890 (H9Q87_22765) | 21624..21911 | - | 288 | WP_071530243.1 | hypothetical protein | - |
| H9Q87_RS22895 (H9Q87_22770) | 22067..22627 | + | 561 | WP_000900095.1 | inverse autotransporter beta domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aac(3)-IId / blaCTX-M-15 / tet(A) | rck / pefD / pefC / pefA / pefB / fdeC / spvC / spvB | 1..110273 | 110273 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11587.48 Da Isoelectric Point: 6.9787
>T170591 WP_001159863.1 NZ_CP060669:17701-18006 [Salmonella enterica]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI
Download Length: 306 bp
>T170591 NZ_CP077649:c3120826-3120362 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 73 a.a. Molecular weight: 8314.16 Da Isoelectric Point: 4.5203
>AT170591 WP_000813641.1 NZ_CP060669:17481-17699 [Salmonella enterica]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW
Download Length: 219 bp
>AT170591 NZ_CP077649:c3121161-3120826 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | I3W3D5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A656ICA6 |