170588

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4376310..4376860 Replicon chromosome
Accession NZ_CP060668
Organism Salmonella enterica strain 190819_2

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag H9Q87_RS21335 Protein ID WP_001199743.1
Coordinates 4376310..4376618 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag H9Q87_RS21340 Protein ID WP_001118105.1
Coordinates 4376621..4376860 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q87_RS21315 (4372884) 4372884..4373624 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
H9Q87_RS21320 (4373746) 4373746..4374276 - 531 WP_234909759.1 SEF14 fimbria major subunit SefA -
H9Q87_RS21325 (4374599) 4374599..4375732 + 1134 Protein_4152 IS3 family transposase -
H9Q87_RS21330 (4375764) 4375764..4375904 - 141 Protein_4153 Arm DNA-binding domain-containing protein -
H9Q87_RS21335 (4376310) 4376310..4376618 - 309 WP_001199743.1 CcdB family protein Toxin
H9Q87_RS21340 (4376621) 4376621..4376860 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
H9Q87_RS21345 (4376969) 4376969..4377217 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
H9Q87_RS21350 (4377408) 4377408..4377839 - 432 Protein_4157 helix-turn-helix domain-containing protein -
H9Q87_RS21360 (4378596) 4378596..4379615 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
H9Q87_RS21365 (4379643) 4379643..4380173 - 531 WP_000896758.1 gluconokinase -
H9Q87_RS21370 (4380390) 4380390..4381421 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4356902..4377217 20315
- inside IScluster/Tn - - 4374691..4377794 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T170588 WP_001199743.1 NZ_CP060668:c4376618-4376310 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T170588 NZ_CP077649:c2050024-2049851 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT170588 WP_001118105.1 NZ_CP060668:c4376860-4376621 [Salmonella enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT170588 NZ_CP077649:c2050348-2050052 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References