Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3756561..3757181 Replicon chromosome
Accession NZ_CP060668
Organism Salmonella enterica strain 190819_2

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag H9Q87_RS18475 Protein ID WP_001280991.1
Coordinates 3756963..3757181 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag H9Q87_RS18470 Protein ID WP_000344807.1
Coordinates 3756561..3756935 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q87_RS18460 (3751700) 3751700..3752893 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
H9Q87_RS18465 (3752916) 3752916..3756065 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
H9Q87_RS18470 (3756561) 3756561..3756935 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
H9Q87_RS18475 (3756963) 3756963..3757181 + 219 WP_001280991.1 HHA domain-containing protein Toxin
H9Q87_RS18480 (3757360) 3757360..3757911 + 552 WP_001278793.1 maltose O-acetyltransferase -
H9Q87_RS18485 (3758029) 3758029..3758499 + 471 WP_000136183.1 YlaC family protein -
H9Q87_RS18490 (3758555) 3758555..3758695 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
H9Q87_RS18495 (3758701) 3758701..3758961 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
H9Q87_RS18500 (3759186) 3759186..3760736 + 1551 WP_000213140.1 EAL domain-containing protein -
H9Q87_RS18510 (3760967) 3760967..3761356 + 390 WP_000961287.1 MGMT family protein -
H9Q87_RS18515 (3761389) 3761389..3761958 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T170583 WP_001280991.1 NZ_CP060668:3756963-3757181 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T170583 NZ_CP077649:437692-437799 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT170583 WP_000344807.1 NZ_CP060668:3756561-3756935 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT170583 NZ_CP077649:c437642-437579 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References