Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 546045..546805 Replicon chromosome
Accession NZ_CP060668
Organism Salmonella enterica strain 190819_2

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag H9Q87_RS02600 Protein ID WP_000533912.1
Coordinates 546320..546805 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag H9Q87_RS02595 Protein ID WP_000965886.1
Coordinates 546045..546332 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q87_RS02575 (541450) 541450..542361 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
H9Q87_RS02580 (542371) 542371..544440 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
H9Q87_RS02585 (544830) 544830..545228 + 399 Protein_491 IS3 family transposase -
H9Q87_RS02590 (545400) 545400..545867 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
H9Q87_RS02595 (546045) 546045..546332 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
H9Q87_RS02600 (546320) 546320..546805 + 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
H9Q87_RS02605 (547176) 547176..547715 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
H9Q87_RS02610 (547889) 547889..548101 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
H9Q87_RS02615 (548389) 548389..548679 - 291 WP_000455790.1 HTH-type transcriptional regulator -
H9Q87_RS02620 (549118) 549118..549828 + 711 WP_000190524.1 DUF3053 domain-containing protein -
H9Q87_RS02625 (549878) 549878..550852 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
H9Q87_RS02630 (551071) 551071..551733 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T170567 WP_000533912.1 NZ_CP060668:546320-546805 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T170567 NZ_CP077646:c2327406-2327095 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTATTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT170567 WP_000965886.1 NZ_CP060668:546045-546332 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT170567 NZ_CP077646:c2327094-2326804 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References