Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 17810..18335 Replicon plasmid unnamed
Accession NZ_CP060667
Organism Salmonella enterica strain 190821_1

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag H9Q88_RS22875 Protein ID WP_001159863.1
Coordinates 18030..18335 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag H9Q88_RS22870 Protein ID WP_000813641.1
Coordinates 17810..18028 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q88_RS22840 (H9Q88_22715) 13424..13810 + 387 WP_000751876.1 YgiW/YdeI family stress tolerance OB fold protein -
H9Q88_RS22845 (H9Q88_22720) 13863..13982 + 120 Protein_18 recombinase -
H9Q88_RS22850 (H9Q88_22725) 14351..15340 - 990 WP_000461382.1 RepB family plasmid replication initiator protein -
H9Q88_RS22855 (H9Q88_22730) 15834..16129 - 296 Protein_20 cytoplasmic protein -
H9Q88_RS22860 (H9Q88_22735) 16141..16569 + 429 Protein_21 hypothetical protein -
H9Q88_RS22865 (H9Q88_22740) 16613..17134 - 522 WP_077681952.1 hypothetical protein -
H9Q88_RS22870 (H9Q88_22745) 17810..18028 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
H9Q88_RS22875 (H9Q88_22750) 18030..18335 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
H9Q88_RS22880 (H9Q88_22755) 18337..18627 + 291 WP_001266176.1 hypothetical protein -
H9Q88_RS22885 (H9Q88_22760) 18624..19145 + 522 WP_000198608.1 hypothetical protein -
H9Q88_RS22890 (H9Q88_22765) 19180..19962 + 783 WP_000082169.1 site-specific integrase -
H9Q88_RS22895 (H9Q88_22770) 19971..20684 + 714 WP_000545756.1 EAL domain-containing protein -
H9Q88_RS22900 (H9Q88_22775) 20709..21197 + 489 WP_001075507.1 CaiF/GrlA family transcriptional regulator -
H9Q88_RS22905 (H9Q88_22780) 21191..21676 + 486 WP_000905606.1 membrane protein -
H9Q88_RS22910 (H9Q88_22785) 21953..22240 - 288 WP_071530243.1 hypothetical protein -
H9Q88_RS22915 (H9Q88_22790) 22396..22956 + 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(3)-IId / blaCTX-M-15 / tet(A) rck / pefD / pefC / pefA / pefB / fdeC / spvC / spvB 1..110273 110273


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11587.48 Da        Isoelectric Point: 6.9787

>T170563 WP_001159863.1 NZ_CP060667:18030-18335 [Salmonella enterica]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI

Download         Length: 306 bp

>T170563 NZ_CP077646:1323863-1324405 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8314.16 Da        Isoelectric Point: 4.5203

>AT170563 WP_000813641.1 NZ_CP060667:17810-18028 [Salmonella enterica]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW

Download         Length: 219 bp

>AT170563 NZ_CP077646:1323568-1323879 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References