Detailed information of TA system TA170562

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 4632105..4632691
• Replicon: chromosome
• Accession: NZ_CP060666
• Organism: Salmonella enterica strain 190821_1

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A3V9X0E4
• Locus tag: H9Q88_RS22545
• Protein ID: WP_000174964.1
• Coordinates: 4632323..4632691 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: V7IU48
• Locus tag: H9Q88_RS22540
• Protein ID: WP_001522145.1
• Coordinates: 4632105..4632326 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q88_RS22515 (4627126)	4627126..4628235	+	1110	WP_000822978.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
H9Q88_RS22520 (4628295)	4628295..4629221	+	927	WP_000003007.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
H9Q88_RS22525 (4629218)	4629218..4630495	+	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
H9Q88_RS22530 (4630492)	4630492..4631259	+	768	WP_000082080.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
H9Q88_RS22535 (4631261)	4631261..4631974	+	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
H9Q88_RS22540 (4632105)	4632105..4632326	+	222	WP_001522145.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H9Q88_RS22545 (4632323)	4632323..4632691	+	369	WP_000174964.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
H9Q88_RS22550 (4632950)	4632950..4634266	+	1317	WP_000624755.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
H9Q88_RS22555 (4634371)	4634371..4635258	+	888	WP_000099303.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
H9Q88_RS22560 (4635255)	4635255..4636100	+	846	WP_000572196.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
H9Q88_RS22565 (4636102)	4636102..4637172	+	1071	WP_000907840.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4621885..4637909	16024

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (6-114)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13601.91 Da
• Isoelectric Point: 6.7252

>T170562 WP_000174964.1 NZ_CP060666:4632323-4632691 [Salmonella enterica]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIVVRLRA

Nucleotide

• Length: 369 bp

>T170562 NZ_CP077646:1289889-1290107 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8166.17 Da
• Isoelectric Point: 5.0775

>AT170562 WP_001522145.1 NZ_CP060666:4632105-4632326 [Salmonella enterica]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRELADK

Nucleotide

• Length: 222 bp

>AT170562 NZ_CP077646:1289489-1289863 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A3V9X0E4