Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4521976..4522736 Replicon chromosome
Accession NZ_CP060666
Organism Salmonella enterica strain 190821_1

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag H9Q88_RS22060 Protein ID WP_000533912.1
Coordinates 4522251..4522736 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag H9Q88_RS22055 Protein ID WP_000965886.1
Coordinates 4521976..4522263 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q88_RS22035 (4517381) 4517381..4518292 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
H9Q88_RS22040 (4518302) 4518302..4520371 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
H9Q88_RS22045 (4520761) 4520761..4521159 + 399 Protein_4290 IS3 family transposase -
H9Q88_RS22050 (4521331) 4521331..4521798 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
H9Q88_RS22055 (4521976) 4521976..4522263 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
H9Q88_RS22060 (4522251) 4522251..4522736 + 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
H9Q88_RS22065 (4523107) 4523107..4523646 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
H9Q88_RS22070 (4523820) 4523820..4524032 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
H9Q88_RS22075 (4524320) 4524320..4524610 - 291 WP_000455790.1 HTH-type transcriptional regulator -
H9Q88_RS22080 (4525049) 4525049..4525759 + 711 WP_000190524.1 DUF3053 domain-containing protein -
H9Q88_RS22085 (4525809) 4525809..4526783 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
H9Q88_RS22090 (4527002) 4527002..4527664 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T170561 WP_000533912.1 NZ_CP060666:4522251-4522736 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T170561 NZ_CP077646:437865-437972 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT170561 WP_000965886.1 NZ_CP060666:4521976-4522263 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT170561 NZ_CP077646:c437815-437752 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References