Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3821338..3822119 Replicon chromosome
Accession NZ_CP060666
Organism Salmonella enterica strain 190821_1

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag H9Q88_RS18845 Protein ID WP_000626100.1
Coordinates 3821338..3821829 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag H9Q88_RS18850 Protein ID WP_001110452.1
Coordinates 3821826..3822119 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q88_RS18810 (3816798) 3816798..3817145 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
H9Q88_RS18815 (3817121) 3817121..3818824 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
H9Q88_RS18820 (3818861) 3818861..3819436 + 576 WP_001188509.1 transcriptional regulator -
H9Q88_RS18830 (3819707) 3819707..3819781 - 75 Protein_3676 helix-turn-helix domain-containing protein -
H9Q88_RS18835 (3820161) 3820161..3820238 + 78 Protein_3677 porin family protein -
H9Q88_RS18840 (3820338) 3820338..3821090 + 753 WP_000842433.1 non-specific acid phosphatase -
H9Q88_RS18845 (3821338) 3821338..3821829 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
H9Q88_RS18850 (3821826) 3821826..3822119 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
H9Q88_RS18855 (3822436) 3822436..3822657 + 222 WP_001576552.1 hypothetical protein -
H9Q88_RS18860 (3822923) 3822923..3823798 + 876 WP_000921676.1 AraC family transcriptional regulator -
H9Q88_RS18865 (3823795) 3823795..3824082 + 288 WP_001541332.1 transcriptional regulator RtsB -
H9Q88_RS18870 (3824075) 3824075..3824383 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
H9Q88_RS18875 (3824382) 3824382..3824630 + 249 Protein_3685 Ig-like domain-containing protein -
H9Q88_RS18880 (3824742) 3824742..3824873 + 132 Protein_3686 hypothetical protein -
H9Q88_RS18885 (3825167) 3825167..3826072 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T170558 WP_000626100.1 NZ_CP060666:c3821829-3821338 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T170558 NZ_CP077646:c231032-230856 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT170558 WP_001110452.1 NZ_CP060666:c3822119-3821826 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT170558 NZ_CP077646:c230810-230394 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References