Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3673317..3673867 Replicon chromosome
Accession NZ_CP060666
Organism Salmonella enterica strain 190821_1

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag H9Q88_RS18060 Protein ID WP_001199743.1
Coordinates 3673317..3673625 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag H9Q88_RS18065 Protein ID WP_001118105.1
Coordinates 3673628..3673867 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q88_RS18040 (3669891) 3669891..3670631 - 741 WP_001676217.1 SEF14/SEF18 fimbria chaperone SefB -
H9Q88_RS18045 (3670753) 3670753..3671283 - 531 WP_234909759.1 SEF14 fimbria major subunit SefA -
H9Q88_RS18050 (3671606) 3671606..3672739 + 1134 Protein_3525 IS3 family transposase -
H9Q88_RS18055 (3672771) 3672771..3672911 - 141 Protein_3526 Arm DNA-binding domain-containing protein -
H9Q88_RS18060 (3673317) 3673317..3673625 - 309 WP_001199743.1 CcdB family protein Toxin
H9Q88_RS18065 (3673628) 3673628..3673867 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
H9Q88_RS18070 (3673976) 3673976..3674224 - 249 WP_000168388.1 ribbon-helix-helix domain-containing protein -
H9Q88_RS18075 (3674415) 3674415..3674846 - 432 Protein_3530 helix-turn-helix domain-containing protein -
H9Q88_RS18085 (3675603) 3675603..3676622 + 1020 WP_000152558.1 NAD(P)-dependent alcohol dehydrogenase -
H9Q88_RS18090 (3676650) 3676650..3677180 - 531 WP_000896758.1 gluconokinase -
H9Q88_RS18095 (3677397) 3677397..3678428 + 1032 WP_000453347.1 L-idonate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3671698..3674801 3103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T170556 WP_001199743.1 NZ_CP060666:c3673625-3673317 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T170556 NZ_CP077639:548628-548978 [Terribacillus sp. DMT04]
TTGATCGTAAAGAGAGGCGAAGTATATTTCGCCGACCTGTCCCCGGTAGTGGGATCAGAACAGGGGGGAGTGCGCCCAGT
ATTGGTCCTGCAGAATGACATCGGCAACAGATTCAGTCCGACAGTCATCGTAGCGGCGATAACAGCGCAAATCCAAAAAG
CCAAGCTGCCGACACATGTGGAGATTGATGCCAAGAAGTATGGTTTTGAACGGGATTCCGTCATTCTTCTGGAACAGATC
CGAACAATCGACAAGCAGCGACTGACAGACAAAATAACACAGCTTGATACGCAAATGATGGAGAATATTAATCGAGCTCT
CGAAATAAGTCTCGGCCTTACAGAGTTTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT170556 WP_001118105.1 NZ_CP060666:c3673867-3673628 [Salmonella enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT170556 NZ_CP077639:548348-548623 [Terribacillus sp. DMT04]
ATGGTTGTGTCCGAAGGCTTACAAGAAATCGTTGTAAAGCTGCCTAAGAAACTCCTAAATGAGGTGGATGGTTTAATGCA
GAATAATAACGACAGTCTCGATCATTTCTTCTATCAAGCAACGAAATCATACGTGCAAGAAAGAAAAGATATCCGTGAAA
CCATGCAAAAAGGATACATGGAAATGGCACGTATCAACTTAAATATCGCTTCAGAAGCTTTCCAAGCTGAAGAGGAGGCA
GAAGTAACGTTAGAGCGCCTTGTAAGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References