Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3629056..3629632 Replicon chromosome
Accession NZ_CP060666
Organism Salmonella enterica strain 190821_1

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag H9Q88_RS17850 Protein ID WP_001131963.1
Coordinates 3629345..3629632 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag H9Q88_RS17845 Protein ID WP_000063142.1
Coordinates 3629056..3629358 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q88_RS17830 (3625566) 3625566..3627716 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
H9Q88_RS17835 (3627811) 3627811..3628014 + 204 WP_000460616.1 YbdD/YjiX family protein -
H9Q88_RS17840 (3628025) 3628025..3628981 + 957 WP_000187843.1 GTPase -
H9Q88_RS17845 (3629056) 3629056..3629358 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
H9Q88_RS17850 (3629345) 3629345..3629632 - 288 WP_001131963.1 BrnT family toxin Toxin
H9Q88_RS17855 (3630049) 3630049..3631305 + 1257 Protein_3486 NERD domain-containing protein/DEAD/DEAH box helicase -
H9Q88_RS17860 (3631299) 3631299..3631478 + 180 Protein_3487 DNA methyltransferase -
H9Q88_RS17865 (3631468) 3631468..3632772 + 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T170555 WP_001131963.1 NZ_CP060666:c3629632-3629345 [Salmonella enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T170555 NZ_CP077638:4350442-4350723 [Methylorubrum extorquens]
ATGCGGACGATTGAGCGAACCACGCAGTTCAAGCGTGACTACAAGCGGGAGATGAAGGGCAGGCACCGGGCGAGCCTTCA
AGCCGACCTGACGGCGGTGCTGACCGAGTTGGCCGCGGATCGCCCCCTCGCGGCGCGCCTGCGTGACCACGCCCTGACCG
GCAACTGGGCCGACCATCGGGACTGCCACGTGAAGCCGGATCTGGTGCTGATCTATCGGCTTGCAGGAACGGAAACGCTC
CAATTGGTGCGCCTCGGCTCGCACGCCGAACTGGGCTTCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT170555 WP_000063142.1 NZ_CP060666:c3629358-3629056 [Salmonella enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT170555 NZ_CP077638:4350192-4350455 [Methylorubrum extorquens]
ATGCCGACCAAGTCGCTGATCCAGGCGCGGATCGATGCCGACACCAAGGAAGAGGCCACAGCCGTTCTCAAGGCCATGGG
GCTGACCGTCTCCGATGCGGTTCGCATGATGCTCGTGCGCGTCGCGCGCGAGAAGGCGCTTCCCTTCGAGCCTCTGGTTC
CCAACGAAACGACCATCGCAGCCATCCGTGAGGCGCGGTCCGGTAACCTTCCGGGCTTCACCAGCGTCGAGGCGCTGATG
GCCGATCTCGATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References