Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3053569..3054189 Replicon chromosome
Accession NZ_CP060666
Organism Salmonella enterica strain 190821_1

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag H9Q88_RS15200 Protein ID WP_001280991.1
Coordinates 3053971..3054189 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag H9Q88_RS15195 Protein ID WP_000344807.1
Coordinates 3053569..3053943 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q88_RS15185 (3048708) 3048708..3049901 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
H9Q88_RS15190 (3049924) 3049924..3053073 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
H9Q88_RS15195 (3053569) 3053569..3053943 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
H9Q88_RS15200 (3053971) 3053971..3054189 + 219 WP_001280991.1 HHA domain-containing protein Toxin
H9Q88_RS15205 (3054368) 3054368..3054919 + 552 WP_001278793.1 maltose O-acetyltransferase -
H9Q88_RS15210 (3055037) 3055037..3055507 + 471 WP_000136183.1 YlaC family protein -
H9Q88_RS15215 (3055563) 3055563..3055703 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
H9Q88_RS15220 (3055709) 3055709..3055969 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
H9Q88_RS15225 (3056194) 3056194..3057744 + 1551 WP_000213140.1 EAL domain-containing protein -
H9Q88_RS15235 (3057975) 3057975..3058364 + 390 WP_000961287.1 MGMT family protein -
H9Q88_RS15240 (3058397) 3058397..3058966 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T170551 WP_001280991.1 NZ_CP060666:3053971-3054189 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T170551 NZ_CP077636:5786-6061 [Campylobacter jejuni]
ATGCAGAATAAATATAGCGTTACTTTTTCTAAAAGGTTTAAAAAAGATTTTAAAAAAATAAATAATAATGATAAAAAAAT
TTTAAAAAAAATAGTCAATAAACTTGCCAATGATGAAGTATTAGAAGAAAAATACAAAGACCACGCACTAAAAGGAAATT
ATATCGGTTTTAGAGAATGCCACATTAAACCTGATTTGTTATTAGTCTATCGCAAAAATAATGATATTTTAGAATTATAT
TTGGCTAATTTAGGAAATCACAATAATATTTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT170551 WP_000344807.1 NZ_CP060666:3053569-3053943 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT170551 NZ_CP077636:5512-5796 [Campylobacter jejuni]
ATGTTTGATTATTCTAAATATGAAAATGCTACTGAAAAACAATTAATACACGCTTTGACTTTAGCAGAAAAAAGAGCAGA
GAAACTAAACTCGCAATTAAAAGAGAATAACGAACTTTTTAAATTTTTACAAAAAAAGTTAAAAAATTCTTTTAACACCA
AAAAAACAAAAAAAGCAGATCAAAGAAGACCTGAATTAGATGAAGCGATTGAAGATTATAAAAATGGAAATGTAGAACAT
TATGCCAATGTAGAAGAAGCGTTTAAGGCTTTAAATGCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References