Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 466152..466812 Replicon chromosome
Accession NZ_CP060666
Organism Salmonella enterica strain 190821_1

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag H9Q88_RS02350 Protein ID WP_000244756.1
Coordinates 466399..466812 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag H9Q88_RS02345 Protein ID WP_000351186.1
Coordinates 466152..466418 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9Q88_RS02325 (462081) 462081..463514 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
H9Q88_RS02330 (463672) 463672..463983 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
H9Q88_RS02335 (464147) 464147..464806 + 660 WP_000250289.1 hemolysin III family protein -
H9Q88_RS02340 (464922) 464922..465902 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
H9Q88_RS02345 (466152) 466152..466418 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
H9Q88_RS02350 (466399) 466399..466812 + 414 WP_000244756.1 protein YgfX Toxin
H9Q88_RS02355 (466865) 466865..467386 - 522 WP_001055885.1 flavodoxin FldB -
H9Q88_RS02360 (467499) 467499..468395 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
H9Q88_RS02365 (468419) 468419..469132 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H9Q88_RS02370 (469138) 469138..470871 + 1734 WP_000813389.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T170538 WP_000244756.1 NZ_CP060666:466399-466812 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T170538 NZ_CP077425:c985490-985200 [Vibrio mimicus]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCTAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACAGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT170538 WP_000351186.1 NZ_CP060666:466152-466418 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT170538 NZ_CP077425:c985728-985480 [Vibrio mimicus]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGCGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAACACCTACGAGCTCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References