170537

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1618002..1618614 Replicon chromosome
Accession NZ_CP060649
Organism Streptococcus pyogenes strain TSPY270

Toxin (Protein)


Gene name parE Uniprot ID Q5X9X8
Locus tag H7786_RS08045 Protein ID WP_011018227.1
Coordinates 1618279..1618614 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag H7786_RS08040 Protein ID WP_002988079.1
Coordinates 1618002..1618289 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7786_RS08015 (H7786_08070) 1613194..1614177 - 984 WP_030126263.1 tagatose-bisphosphate aldolase -
H7786_RS08020 (H7786_08075) 1614181..1615110 - 930 WP_030126262.1 tagatose-6-phosphate kinase -
H7786_RS08025 (H7786_08080) 1615156..1615671 - 516 WP_014407849.1 galactose-6-phosphate isomerase subunit LacB -
H7786_RS08030 (H7786_08085) 1615706..1616134 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
H7786_RS08035 (H7786_08090) 1616579..1617352 + 774 WP_002993783.1 DeoR/GlpR family DNA-binding transcription regulator -
H7786_RS08040 (H7786_08095) 1618002..1618289 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
H7786_RS08045 (H7786_08100) 1618279..1618614 + 336 WP_011018227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7786_RS08050 1618712..1619700 + 989 Protein_1532 site-specific integrase -
H7786_RS08055 (H7786_08115) 1619868..1620260 - 393 WP_030126260.1 30S ribosomal protein S9 -
H7786_RS08060 (H7786_08120) 1620281..1620727 - 447 WP_002982710.1 50S ribosomal protein L13 -
H7786_RS08065 (H7786_08125) 1620945..1621151 - 207 WP_011285176.1 helix-turn-helix transcriptional regulator -
H7786_RS08070 (H7786_08130) 1621148..1621846 - 699 WP_030126259.1 hypothetical protein -
H7786_RS08075 (H7786_08135) 1621982..1622842 - 861 WP_030126258.1 DegV family protein -
H7786_RS08080 (H7786_08140) 1622939..1623457 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13171.97 Da        Isoelectric Point: 5.2144

>T170537 WP_011018227.1 NZ_CP060649:1618279-1618614 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T170537 NZ_CP077425:c47457-46960 [Vibrio mimicus]
ATGATGAATACGGTACTTCTCGATAAATTTAAGCACGATAGGAACCGTTTCAATTGTGGCATTGAAGCCCTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACACCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCTTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGATTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGCGTAGCGTTCCCTGTTGTCATCGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCACTATGGGTTTAAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT170537 WP_002988079.1 NZ_CP060649:1618002-1618289 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT170537 NZ_CP077425:c47726-47454 [Vibrio mimicus]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCACTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCGGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCGGTAGCAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2QKE7

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References