Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 235929..236541 Replicon chromosome
Accession NZ_CP060648
Organism Streptococcus pyogenes strain TSPY383

Toxin (Protein)


Gene name parE Uniprot ID J7M9F1
Locus tag H7787_RS01235 Protein ID WP_010922665.1
Coordinates 235929..236264 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag H7787_RS01240 Protein ID WP_002988079.1
Coordinates 236254..236541 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7787_RS01200 (H7787_01195) 231307..231825 + 519 WP_002982682.1 NYN domain-containing protein -
H7787_RS01205 (H7787_01200) 231922..232782 + 861 WP_002982687.1 DegV family protein -
H7787_RS01210 (H7787_01205) 232918..233424 + 507 WP_002988070.1 hypothetical protein -
H7787_RS01215 (H7787_01210) 233421..233627 + 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
H7787_RS01220 (H7787_01215) 233845..234291 + 447 WP_002982710.1 50S ribosomal protein L13 -
H7787_RS01225 (H7787_01220) 234312..234704 + 393 WP_002982716.1 30S ribosomal protein S9 -
H7787_RS01230 234824..235831 - 1008 Protein_218 site-specific integrase -
H7787_RS01235 (H7787_01235) 235929..236264 - 336 WP_010922665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7787_RS01240 (H7787_01240) 236254..236541 - 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
H7787_RS01245 (H7787_01245) 237202..237975 - 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
H7787_RS01250 (H7787_01250) 238422..238850 + 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
H7787_RS01255 (H7787_01255) 238885..239400 + 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
H7787_RS01260 (H7787_01260) 239448..240377 + 930 WP_010922663.1 tagatose-6-phosphate kinase -
H7787_RS01265 (H7787_01265) 240381..241364 + 984 WP_002982755.1 tagatose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13185.99 Da        Isoelectric Point: 5.2144

>T170536 WP_010922665.1 NZ_CP060648:c236264-235929 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T170536 NZ_CP077425:43576-43863 [Vibrio mimicus]
ATGAAAGTAGTTTGGTCACCTCTAGCGTTACAAAAACTGGGTGATGCCGCAGAGTTTATTGCTTTGGATAACCCATCAGC
TGCAGAAAAGTGGGTGAATGAAGTATTCGACAAAACGGAATTGCTCGGCTCAATGCCAGAAATGGGCCGCATGGTTCCTG
AAATGCCTCATACGAACTACCGTGAAATAATTTTTGGTCATTACCGCATTATTTATAGTTTGAGCCACGAAATCCGCGTT
CTAACAGTTCGTAACTGTCGTCAATTGCTCACGGAACATGATGTGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT170536 WP_002988079.1 NZ_CP060648:c236541-236254 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT170536 NZ_CP077425:43298-43579 [Vibrio mimicus]
ATGAGCCGTATTCACCTTGATCAAGATATTCAGCCTTTGTCTGAGTTCCGTGCTGGCGTTGCATCATTTATCAAACAGAT
CAATGAGACTCGTCGACCATTGGTTATTACACAACGAGGTAAAGGTGTAGCCGTTGTTCTTGACGTTGCGGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTCGAAGAAATGCGTACTGCAGAAGCTCAATTGGCTGCAGGTTTAGGTATATCAAAC
GAAGATGCTCGTTCACAAGTTCTGGGGCGCATCATCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J7M9F1

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References