Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1547839..1548451 Replicon chromosome
Accession NZ_CP060647
Organism Streptococcus pyogenes strain TSPY136

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag H7788_RS07735 Protein ID WP_002988077.1
Coordinates 1548116..1548451 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag H7788_RS07730 Protein ID WP_002988079.1
Coordinates 1547839..1548126 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7788_RS07705 (H7788_07705) 1543031..1544014 - 984 WP_011184964.1 tagatose-bisphosphate aldolase -
H7788_RS07710 (H7788_07710) 1544018..1544947 - 930 WP_030127320.1 tagatose-6-phosphate kinase -
H7788_RS07715 (H7788_07715) 1544993..1545508 - 516 WP_030127321.1 galactose-6-phosphate isomerase subunit LacB -
H7788_RS07720 (H7788_07720) 1545543..1545971 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
H7788_RS07725 (H7788_07725) 1546416..1547189 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
H7788_RS07730 (H7788_07730) 1547839..1548126 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
H7788_RS07735 (H7788_07735) 1548116..1548451 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7788_RS07740 1548549..1549584 + 1036 Protein_1468 site-specific integrase -
H7788_RS07745 (H7788_07750) 1549716..1550108 - 393 WP_002982716.1 30S ribosomal protein S9 -
H7788_RS07750 (H7788_07755) 1550129..1550575 - 447 WP_011018228.1 50S ribosomal protein L13 -
H7788_RS07755 (H7788_07760) 1550793..1550999 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
H7788_RS07760 (H7788_07765) 1550996..1551694 - 699 WP_030127323.1 hypothetical protein -
H7788_RS07765 (H7788_07770) 1551830..1552690 - 861 WP_030127324.1 DegV family protein -
H7788_RS07770 (H7788_07775) 1552787..1553305 - 519 WP_011889154.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T170535 WP_002988077.1 NZ_CP060647:1548116-1548451 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T170535 NZ_CP077425:31147-31416 [Vibrio mimicus]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTTTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTCGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTAAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT170535 WP_002988079.1 NZ_CP060647:1547839-1548126 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT170535 NZ_CP077425:31410-31931 [Vibrio mimicus]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAATGCACCTTTTTCAGAAATTAAAGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References