170534

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1617368..1617980 Replicon chromosome
Accession NZ_CP060646
Organism Streptococcus pyogenes strain TSPY1026

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag H7789_RS07970 Protein ID WP_002982731.1
Coordinates 1617645..1617980 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag H7789_RS07965 Protein ID WP_002988079.1
Coordinates 1617368..1617655 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7789_RS07940 (H7789_07930) 1612546..1613529 - 984 WP_014407847.1 tagatose-bisphosphate aldolase -
H7789_RS07945 (H7789_07935) 1613533..1614462 - 930 WP_023609980.1 tagatose-6-phosphate kinase -
H7789_RS07950 (H7789_07940) 1614510..1615025 - 516 WP_023612880.1 galactose-6-phosphate isomerase subunit LacB -
H7789_RS07955 (H7789_07945) 1615060..1615488 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
H7789_RS07960 (H7789_07950) 1615934..1616707 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
H7789_RS07965 (H7789_07955) 1617368..1617655 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
H7789_RS07970 (H7789_07960) 1617645..1617980 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7789_RS07975 1618078..1619065 + 988 Protein_1515 site-specific integrase -
H7789_RS07980 1619433..1619519 - 87 WP_227874724.1 type II toxin-antitoxin system RelE/ParE family toxin -
H7789_RS07985 (H7789_07975) 1619519..1619743 - 225 WP_227874722.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - ska 1615912..1685158 69246


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T170534 WP_002982731.1 NZ_CP060646:1617645-1617980 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T170534 NZ_CP077425:c26686-26408 [Vibrio mimicus]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCCGC
TGAAAAAACGGACGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATGGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT170534 WP_002988079.1 NZ_CP060646:1617368-1617655 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT170534 NZ_CP077425:c26967-26683 [Vibrio mimicus]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTCTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGTCGTGAACTCACTGAACAATTAGCTGAGCAACAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References