170533

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1640815..1641427 Replicon chromosome
Accession NZ_CP060645
Organism Streptococcus pyogenes strain TSPY1349

Toxin (Protein)


Gene name parE Uniprot ID A0A0H3C0F8
Locus tag H7790_RS08155 Protein ID WP_009880846.1
Coordinates 1641092..1641427 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag H7790_RS08150 Protein ID WP_002988079.1
Coordinates 1640815..1641102 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7790_RS08125 (H7790_08145) 1636007..1636990 - 984 WP_115230695.1 tagatose-bisphosphate aldolase -
H7790_RS08130 (H7790_08150) 1636994..1637923 - 930 WP_115230696.1 tagatose-6-phosphate kinase -
H7790_RS08135 (H7790_08155) 1637969..1638484 - 516 WP_014407849.1 galactose-6-phosphate isomerase subunit LacB -
H7790_RS08140 (H7790_08160) 1638519..1638947 - 429 WP_115230697.1 galactose-6-phosphate isomerase subunit LacA -
H7790_RS08145 (H7790_08165) 1639392..1640165 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
H7790_RS08150 (H7790_08170) 1640815..1641102 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
H7790_RS08155 (H7790_08175) 1641092..1641427 + 336 WP_009880846.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7790_RS08160 1641525..1642513 + 989 Protein_1568 site-specific integrase -
H7790_RS08165 (H7790_08190) 1642847..1643176 - 330 Protein_1569 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - ska 1639370..1708615 69245


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13204.95 Da        Isoelectric Point: 5.6809

>T170533 WP_009880846.1 NZ_CP060645:1641092-1641427 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFREVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T170533 NZ_CP077425:17939-18226 [Vibrio mimicus]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTATGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT170533 WP_002988079.1 NZ_CP060645:1640815-1641102 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT170533 NZ_CP077425:18237-18554 [Vibrio mimicus]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTGATCAATGGCGGAGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCAGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3C0F8

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References