Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1539439..1540051 Replicon chromosome
Accession NZ_CP060643
Organism Streptococcus pyogenes strain TSPY416

Toxin (Protein)


Gene name parE Uniprot ID A0A0H3C0F8
Locus tag H7792_RS07555 Protein ID WP_009880846.1
Coordinates 1539716..1540051 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag H7792_RS07550 Protein ID WP_002988079.1
Coordinates 1539439..1539726 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7792_RS07525 (H7792_07505) 1534617..1535600 - 984 WP_136284948.1 tagatose-bisphosphate aldolase -
H7792_RS07530 (H7792_07510) 1535604..1536533 - 930 WP_111713944.1 tagatose-6-phosphate kinase -
H7792_RS07535 (H7792_07515) 1536581..1537096 - 516 WP_011285170.1 galactose-6-phosphate isomerase subunit LacB -
H7792_RS07540 (H7792_07520) 1537131..1537559 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
H7792_RS07545 (H7792_07525) 1538005..1538778 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
H7792_RS07550 (H7792_07530) 1539439..1539726 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
H7792_RS07555 (H7792_07535) 1539716..1540051 + 336 WP_009880846.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7792_RS07560 1540149..1541183 + 1035 Protein_1436 site-specific integrase -
H7792_RS07565 (H7792_07550) 1541303..1541695 - 393 WP_002982716.1 30S ribosomal protein S9 -
H7792_RS07570 (H7792_07555) 1541716..1542162 - 447 WP_002982710.1 50S ribosomal protein L13 -
H7792_RS07575 (H7792_07560) 1542380..1542586 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
H7792_RS07580 (H7792_07565) 1542583..1543281 - 699 WP_023605294.1 hypothetical protein -
H7792_RS07585 (H7792_07570) 1543417..1544277 - 861 WP_002982687.1 DegV family protein -
H7792_RS07590 (H7792_07575) 1544374..1544892 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13204.95 Da        Isoelectric Point: 5.6809

>T170532 WP_009880846.1 NZ_CP060643:1539716-1540051 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFREVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T170532 NZ_CP077425:17939-18226 [Vibrio mimicus]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTATGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT170532 WP_002988079.1 NZ_CP060643:1539439-1539726 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT170532 NZ_CP077425:17776-17898 [Vibrio mimicus]
GTGGTTTCGGTTGTTGTGATTGAGTTTAGTGGTATGCGTTGCCAGCCCCTTAGGCGGGCGTTATGTACTTTTCTGAAATC
CTTCCTACAAGTCAAACTTGTGCACAATGTCATTATGCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3C0F8

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References