170531

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1607763..1608375 Replicon chromosome
Accession NZ_CP060642
Organism Streptococcus pyogenes strain TSPY1312

Toxin (Protein)


Gene name parE Uniprot ID Q1JJZ2
Locus tag H7793_RS08035 Protein ID WP_002988077.1
Coordinates 1608040..1608375 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag H7793_RS08030 Protein ID WP_002988079.1
Coordinates 1607763..1608050 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7793_RS08005 (H7793_08005) 1602954..1603937 - 984 WP_002988088.1 tagatose-bisphosphate aldolase -
H7793_RS08010 (H7793_08010) 1603941..1604870 - 930 WP_002988085.1 tagatose-6-phosphate kinase -
H7793_RS08015 (H7793_08015) 1604916..1605431 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
H7793_RS08020 (H7793_08020) 1605466..1605894 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
H7793_RS08025 (H7793_08025) 1606340..1607113 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
H7793_RS08030 (H7793_08030) 1607763..1608050 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
H7793_RS08035 (H7793_08035) 1608040..1608375 + 336 WP_002988077.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7793_RS08040 1608473..1609507 + 1035 Protein_1529 site-specific integrase -
H7793_RS08045 (H7793_08055) 1609627..1610019 - 393 WP_002982716.1 30S ribosomal protein S9 -
H7793_RS08050 (H7793_08060) 1610040..1610486 - 447 WP_002982710.1 50S ribosomal protein L13 -
H7793_RS08055 (H7793_08065) 1610704..1610910 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
H7793_RS08060 (H7793_08070) 1610907..1611413 - 507 WP_002988070.1 hypothetical protein -
H7793_RS08065 (H7793_08075) 1611549..1612409 - 861 WP_002982687.1 DegV family protein -
H7793_RS08070 (H7793_08080) 1612506..1613024 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13117.83 Da        Isoelectric Point: 5.2144

>T170531 WP_002988077.1 NZ_CP060642:1608040-1608375 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVAIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T170531 NZ_CP077425:16794-17096 [Vibrio mimicus]
ATGGCTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTCGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTT
TAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTATAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT170531 WP_002988079.1 NZ_CP060642:1607763-1608050 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT170531 NZ_CP077425:16549-16806 [Vibrio mimicus]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGTGGAGAGCGAGCTCTAGCGGATGGCAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A236

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References