Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1590341..1590953 Replicon chromosome
Accession NZ_CP060641
Organism Streptococcus pyogenes strain TSPY210

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag H7795_RS07925 Protein ID WP_002982731.1
Coordinates 1590618..1590953 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag H7795_RS07920 Protein ID WP_002988079.1
Coordinates 1590341..1590628 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7795_RS07895 (H7795_07865) 1585521..1586504 - 984 WP_023610648.1 tagatose-bisphosphate aldolase -
H7795_RS07900 (H7795_07870) 1586508..1587437 - 930 WP_023612888.1 tagatose-6-phosphate kinase -
H7795_RS07905 (H7795_07875) 1587483..1587998 - 516 WP_023612880.1 galactose-6-phosphate isomerase subunit LacB -
H7795_RS07910 (H7795_07880) 1588033..1588461 - 429 WP_023612877.1 galactose-6-phosphate isomerase subunit LacA -
H7795_RS07915 (H7795_07885) 1588907..1589680 + 774 WP_023612896.1 DeoR/GlpR family DNA-binding transcription regulator -
H7795_RS07920 (H7795_07890) 1590341..1590628 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
H7795_RS07925 (H7795_07895) 1590618..1590953 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7795_RS07930 1591051..1592085 + 1035 Protein_1506 site-specific integrase -
H7795_RS07935 (H7795_07915) 1592218..1592610 - 393 WP_002982716.1 30S ribosomal protein S9 -
H7795_RS07940 (H7795_07920) 1592631..1593077 - 447 WP_002982710.1 50S ribosomal protein L13 -
H7795_RS07945 (H7795_07925) 1593295..1593501 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
H7795_RS07950 (H7795_07930) 1593498..1594196 - 699 WP_011018229.1 hypothetical protein -
H7795_RS07955 (H7795_07935) 1594332..1595192 - 861 WP_023612881.1 DegV family protein -
H7795_RS07960 (H7795_07940) 1595289..1595807 - 519 WP_023612882.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T170530 WP_002982731.1 NZ_CP060641:1590618-1590953 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T170530 NZ_CP077425:c10550-10233 [Vibrio mimicus]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGGTTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTAGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT170530 WP_002988079.1 NZ_CP060641:1590341-1590628 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT170530 NZ_CP077425:c10811-10569 [Vibrio mimicus]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATGGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References