Detailed information of TA system TA170529

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1497242..1497854
• Replicon: chromosome
• Accession: NZ_CP060640
• Organism: Streptococcus pyogenes strain TSPY764

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q1JEY4
• Locus tag: H7796_RS07275
• Protein ID: WP_020905490.1
• Coordinates: 1497519..1497854 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: H7796_RS07270
• Protein ID: WP_002988079.1
• Coordinates: 1497242..1497529 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7796_RS07245 (H7796_07255)	1492422..1493405	-	984	WP_002988088.1	tagatose-bisphosphate aldolase	-
H7796_RS07250 (H7796_07260)	1493409..1494338	-	930	WP_002988085.1	tagatose-6-phosphate kinase	-
H7796_RS07255 (H7796_07265)	1494384..1494899	-	516	WP_020905489.1	galactose-6-phosphate isomerase subunit LacB	-
H7796_RS07260 (H7796_07270)	1494934..1495362	-	429	WP_011529004.1	galactose-6-phosphate isomerase subunit LacA	-
H7796_RS07265 (H7796_07275)	1495808..1496581	+	774	WP_011285171.1	DeoR/GlpR family DNA-binding transcription regulator	-
H7796_RS07270 (H7796_07280)	1497242..1497529	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
H7796_RS07275 (H7796_07285)	1497519..1497854	+	336	WP_020905490.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H7796_RS07280	1497952..1498939	+	988	Protein_1376	site-specific integrase	-
H7796_RS07285 (H7796_07300)	1499107..1499499	-	393	WP_002982716.1	30S ribosomal protein S9	-
H7796_RS07290 (H7796_07305)	1499520..1499966	-	447	WP_002982710.1	50S ribosomal protein L13	-
H7796_RS07295 (H7796_07310)	1500184..1500390	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
H7796_RS07300 (H7796_07315)	1500387..1501085	-	699	WP_228631311.1	hypothetical protein	-
H7796_RS07305 (H7796_07320)	1501221..1502081	-	861	WP_002982687.1	DegV family protein	-
H7796_RS07310 (H7796_07325)	1502178..1502696	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13147.98 Da
• Isoelectric Point: 4.9405

>T170529 WP_020905490.1 NZ_CP060640:1497519-1497854 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIILYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T170529 NZ_CP077425:c8426-8127 [Vibrio mimicus]
ATGAAACCATTTAATCTTACTGTCGCCGCTAAAGCCGATTTACGGGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATCAGTAAATCAT
GCGATGAAATTCGAGAGGGATACAGAAAATTTCCCCAAGGGAGCCACGTCATCTTTTATCAGCAAATCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTTGGCGCATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT170529 WP_002988079.1 NZ_CP060640:1497242-1497529 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT170529 NZ_CP077425:c8665-8423 [Vibrio mimicus]
ATGGCTAAAAACACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGACGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAATTAC
TTGTTGAAGGTGAGCAAAGTGGTGATGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Structures

Toxin

• AlphaFold DB: Q1JEY4

Antitoxin

• AlphaFold DB: A0A4U7GX94