Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1497242..1497854 Replicon chromosome
Accession NZ_CP060640
Organism Streptococcus pyogenes strain TSPY764

Toxin (Protein)


Gene name parE Uniprot ID Q1JEY4
Locus tag H7796_RS07275 Protein ID WP_020905490.1
Coordinates 1497519..1497854 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag H7796_RS07270 Protein ID WP_002988079.1
Coordinates 1497242..1497529 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7796_RS07245 (H7796_07255) 1492422..1493405 - 984 WP_002988088.1 tagatose-bisphosphate aldolase -
H7796_RS07250 (H7796_07260) 1493409..1494338 - 930 WP_002988085.1 tagatose-6-phosphate kinase -
H7796_RS07255 (H7796_07265) 1494384..1494899 - 516 WP_020905489.1 galactose-6-phosphate isomerase subunit LacB -
H7796_RS07260 (H7796_07270) 1494934..1495362 - 429 WP_011529004.1 galactose-6-phosphate isomerase subunit LacA -
H7796_RS07265 (H7796_07275) 1495808..1496581 + 774 WP_011285171.1 DeoR/GlpR family DNA-binding transcription regulator -
H7796_RS07270 (H7796_07280) 1497242..1497529 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
H7796_RS07275 (H7796_07285) 1497519..1497854 + 336 WP_020905490.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7796_RS07280 1497952..1498939 + 988 Protein_1376 site-specific integrase -
H7796_RS07285 (H7796_07300) 1499107..1499499 - 393 WP_002982716.1 30S ribosomal protein S9 -
H7796_RS07290 (H7796_07305) 1499520..1499966 - 447 WP_002982710.1 50S ribosomal protein L13 -
H7796_RS07295 (H7796_07310) 1500184..1500390 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
H7796_RS07300 (H7796_07315) 1500387..1501085 - 699 WP_228631311.1 hypothetical protein -
H7796_RS07305 (H7796_07320) 1501221..1502081 - 861 WP_002982687.1 DegV family protein -
H7796_RS07310 (H7796_07325) 1502178..1502696 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13147.98 Da        Isoelectric Point: 4.9405

>T170529 WP_020905490.1 NZ_CP060640:1497519-1497854 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIILYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T170529 NZ_CP077425:c8426-8127 [Vibrio mimicus]
ATGAAACCATTTAATCTTACTGTCGCCGCTAAAGCCGATTTACGGGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATCAGTAAATCAT
GCGATGAAATTCGAGAGGGATACAGAAAATTTCCCCAAGGGAGCCACGTCATCTTTTATCAGCAAATCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTTGGCGCATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT170529 WP_002988079.1 NZ_CP060640:1497242-1497529 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT170529 NZ_CP077425:c8665-8423 [Vibrio mimicus]
ATGGCTAAAAACACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGACGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAATTAC
TTGTTGAAGGTGAGCAAAGTGGTGATGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q1JEY4

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References