Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 932046..933289 Replicon chromosome
Accession NZ_CP060639
Organism Streptococcus pyogenes strain TSPY153

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag H7797_RS04695 Protein ID WP_111693193.1
Coordinates 932522..933289 (+) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag H7797_RS04690 Protein ID WP_111693192.1
Coordinates 932046..932522 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7797_RS04660 (H7797_04635) 929308..929475 + 168 Protein_875 calcium-binding protein -
H7797_RS04665 (H7797_04640) 929482..929679 + 198 Protein_876 hypothetical protein -
H7797_RS04670 (H7797_04645) 929748..930853 + 1106 WP_111693067.1 IS3 family transposase -
H7797_RS04675 (H7797_04650) 931024..931245 + 222 WP_111693189.1 DUF5965 family protein -
H7797_RS04680 (H7797_04655) 931249..931644 + 396 WP_111693190.1 DUF5945 family protein -
H7797_RS04685 (H7797_04660) 931689..931976 + 288 WP_111693191.1 hypothetical protein -
H7797_RS04690 (H7797_04665) 932046..932522 + 477 WP_111693192.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
H7797_RS04695 (H7797_04670) 932522..933289 + 768 WP_111693193.1 type II toxin-antitoxin system toxin PezT Toxin
H7797_RS04700 (H7797_04675) 933305..934093 + 789 WP_029174746.1 DUF6414 family protein -
H7797_RS04705 (H7797_04680) 934094..935236 + 1143 WP_111693194.1 AAA family ATPase -
H7797_RS04710 (H7797_04685) 935563..935922 + 360 WP_111693195.1 SAG1252 family conjugative relaxosome accessory protein -
H7797_RS04715 (H7797_04690) 935932..936297 + 366 WP_111693196.1 plasmid mobilization relaxosome protein MobC -
H7797_RS04720 (H7797_04695) 936284..936676 + 393 Protein_887 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 907382..948993 41611


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29238.18 Da        Isoelectric Point: 6.3613

>T170527 WP_111693193.1 NZ_CP060639:932522-933289 [Streptococcus pyogenes]
MRLEEFSQDDFDLALKRTIRSLTRGKTTSVTPKAILLGRQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRPLHPNYLDLQE
KYGKDSVDYTKGFAEKMVEQLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKSRGYQVSLALIATKPELSYLSTLIRYEE
VYAVNPNQARATPKGHHDGIVERLVDNLRELETNKLFDQIQIYQRDRTCVYDSETDEGPAADVLQDCLFGKWSKVEEEML
RDIEEKIANLKVSNE

Download         Length: 768 bp

>T170527 NZ_CP077423:c1499771-1499583 [Streptococcus gallolyticus subsp. gallolyticus TX20005]
GTGCCGTTAACAGGCAGAGAGTTAGCAAAACTTGCTGTGTTAAAAGGTTGGAAAGAAGTTCGTGTAAAGGGAAGTCATCA
TCAGTTCAAAAAGGATGGCGTACCCTATATTCTTACAATTCCAATTCATGGCAACAAGGTGTTAGGTGTAGGTTTGGAAA
AGAAAATTTTAAAAGACATAGGGCTATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18162.57 Da        Isoelectric Point: 4.6103

>AT170527 WP_111693192.1 NZ_CP060639:932046-932522 [Streptococcus pyogenes]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQKIAFDDETNPWILMSDDLSDLINTKIYLVQSFDEVERYNGYLDGIERILNLAHHQVVA

Download         Length: 477 bp

>AT170527 NZ_CP077423:c1499571-1499191 [Streptococcus gallolyticus subsp. gallolyticus TX20005]
ATGTTAAAATCATATCCAGCAATTTTTCACAAAGAAGATGATGGAAGTTTTTGGGTAGAATTTCCAGGATTTGGTGGTGG
TACCGAAGGTGATGATGTCGAAGAAGCGATGAAAAATGCTCGAGAAATGTTAGAAAGCTCATTGGCTGCTTATCTAGATG
AAGGTTTAGAGCTTCCAAAGGTTGTTAATATGAGTGAATTATCAGTTGAAGATGGTTTTATCACTTTAATTCAAGCAGAC
CCTTCCCCATATTTAAAAAGTACCAAAGCCATTCGAAAAAATGTTACTGTTCCAGAATGGTTAGTCAGATTAGCAGACCG
TGAGAATGTGAATTACTCGGAGGTTTTGACACAAGCTTTAGAGAAAAAATTACAGCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References