Detailed information of TA system TA170526

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1644362..1644974
• Replicon: chromosome
• Accession: NZ_CP060638
• Organism: Streptococcus pyogenes strain TSPY141

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q5X9X8
• Locus tag: H7798_RS08150
• Protein ID: WP_011018227.1
• Coordinates: 1644639..1644974 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: H7798_RS08145
• Protein ID: WP_002988079.1
• Coordinates: 1644362..1644649 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7798_RS08120 (H7798_08155)	1639553..1640536	-	984	WP_030126263.1	tagatose-bisphosphate aldolase	-
H7798_RS08125 (H7798_08160)	1640540..1641469	-	930	WP_030126262.1	tagatose-6-phosphate kinase	-
H7798_RS08130 (H7798_08165)	1641515..1642030	-	516	WP_014407849.1	galactose-6-phosphate isomerase subunit LacB	-
H7798_RS08135 (H7798_08170)	1642065..1642493	-	429	WP_011529004.1	galactose-6-phosphate isomerase subunit LacA	-
H7798_RS08140 (H7798_08175)	1642939..1643712	+	774	WP_002993783.1	DeoR/GlpR family DNA-binding transcription regulator	-
H7798_RS08145 (H7798_08180)	1644362..1644649	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
H7798_RS08150 (H7798_08185)	1644639..1644974	+	336	WP_011018227.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H7798_RS08155	1645072..1646060	+	989	Protein_1565	site-specific integrase	-
H7798_RS08160 (H7798_08200)	1646228..1646620	-	393	WP_030126260.1	30S ribosomal protein S9	-
H7798_RS08165 (H7798_08205)	1646641..1647087	-	447	WP_002982710.1	50S ribosomal protein L13	-
H7798_RS08170 (H7798_08210)	1647305..1647511	-	207	WP_011285176.1	helix-turn-helix transcriptional regulator	-
H7798_RS08175 (H7798_08215)	1647508..1648206	-	699	WP_030126259.1	hypothetical protein	-
H7798_RS08180 (H7798_08220)	1648342..1649202	-	861	WP_030126258.1	DegV family protein	-
H7798_RS08185 (H7798_08225)	1649299..1649817	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13171.97 Da
• Isoelectric Point: 5.2144

>T170526 WP_011018227.1 NZ_CP060638:1644639-1644974 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T170526 NZ_CP077423:c1128369-1128112 [Streptococcus gallolyticus subsp. gallolyticus TX20005]
ATGATTAAAGCATGGTCTGACGATGCGTGGAACGACTATATGTATTGGTATAATCAAGGAAATAAAGCGACAATTAAAAA
AATTAATCGCCTAATCAAGGAGATTGACCGCACTCCTTTTACTGGCATTGGTAAACCTGAACCACTTAAACACGATTTAT
CTGGCAAATGGTCACGACGCATAACCGATGAACATCGTTTAATTTACAGTGTTGATGAGACTACTATTTACTTTTATTCT
TGCAAAGACCATTATTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT170526 WP_002988079.1 NZ_CP060638:1644362-1644649 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT170526 NZ_CP077423:c1128628-1128362 [Streptococcus gallolyticus subsp. gallolyticus TX20005]
ATGGAAGTTGTTGCATATTCAAATTTTAGACAAAATTTAAAACATTATATGAAACAAGTTAACGATGACGCTGAACCGCT
TATTGTGACTTCTAAAAATATTGATGATACTGTCGTAGTCCTTTCAAAACGTGACTATGATAGCATGCAAGAAACATTTC
GCATTATGTCTAATAACTACCTAATGAATAAAATTAAACGCGGCGATGAACAATTCAAAGCAGCTAATTTTCAGACACAT
GAATTGCTCGAGGTAGATGATGATTAA

Structures

Toxin

• AlphaFold DB: A0A7Z2QKE7

Antitoxin

• AlphaFold DB: A0A4U7GX94