Detailed information of TA system TA170523

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2688100..2688665
• Replicon: chromosome
• Accession: NZ_CP060633
• Organism: Simiaoa sunii strain NSJ-8

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H9Q77_RS12430
• Protein ID: WP_249325781.1
• Coordinates: 2688100..2688390 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C7H6P4
• Locus tag: H9Q77_RS12435
• Protein ID: WP_005924829.1
• Coordinates: 2688387..2688665 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q77_RS12400 (H9Q77_12410)	2683933..2684166	+	234	WP_249325776.1	permease	-
H9Q77_RS12405 (H9Q77_12415)	2684630..2685043	+	414	WP_249325778.1	sigma factor-like helix-turn-helix DNA-binding protein	-
H9Q77_RS12410 (H9Q77_12420)	2685147..2685599	+	453	WP_119624259.1	RNA polymerase subunit sigma-24	-
H9Q77_RS12415 (H9Q77_12425)	2685610..2686071	+	462	WP_009296689.1	sigma factor-like helix-turn-helix DNA-binding protein	-
H9Q77_RS12420 (H9Q77_12430)	2686100..2686390	+	291	WP_119194479.1	DUF3847 domain-containing protein	-
H9Q77_RS12425 (H9Q77_12435)	2686577..2688022	+	1446	WP_249325779.1	MobQ family relaxase	-
H9Q77_RS12430 (H9Q77_12440)	2688100..2688390	-	291	WP_249325781.1	type II toxin-antitoxin system YafQ family toxin	Toxin
H9Q77_RS12435 (H9Q77_12445)	2688387..2688665	-	279	WP_005924829.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
H9Q77_RS12440 (H9Q77_12450)	2688792..2689190	+	399	WP_249325783.1	cysteine-rich VLP domain-containing protein	-
H9Q77_RS12445 (H9Q77_12455)	2689304..2690053	+	750	WP_249325784.1	phage replisome organizer N-terminal domain-containing protein	-
H9Q77_RS12450 (H9Q77_12460)	2690050..2690913	+	864	WP_249325786.1	ATP-binding protein	-
H9Q77_RS12455 (H9Q77_12465)	2690957..2691151	+	195	WP_118685214.1	transposon-encoded TnpW family protein	-
H9Q77_RS12460 (H9Q77_12470)	2691229..2691594	+	366	WP_097791876.1	hypothetical protein	-
H9Q77_RS12465 (H9Q77_12475)	2691689..2692519	+	831	Protein_2438	TraM recognition domain-containing protein	-
H9Q77_RS12470 (H9Q77_12480)	2692764..2692892	+	129	Protein_2439	Maff2 family protein	-
H9Q77_RS12475 (H9Q77_12485)	2693286..2693645	+	360	WP_008704785.1	BlaI/MecI/CopY family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2684630..2701714	17084

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-94)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-90)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11099.87 Da
• Isoelectric Point: 8.0630

>T170523 WP_249325781.1 NZ_CP060633:c2688390-2688100 [Simiaoa sunii]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKTRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Nucleotide

• Length: 291 bp

>T170523 NZ_CP077422:c2332811-2332731 [Dickeya dadantii]
AATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGGGCACAGGAATCGTGTTCGGTCTTTTTT
T

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10247.66 Da
• Isoelectric Point: 4.4692

>AT170523 WP_005924829.1 NZ_CP060633:c2688665-2688387 [Simiaoa sunii]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Nucleotide

• Length: 279 bp

>AT170523 NZ_CP077422:2332729-2332811 [Dickeya dadantii]
ATAAAAAAAGACCGAACACGATTCCTGTGCCCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATT

Structures

Antitoxin

• AlphaFold DB: A0A1M4XB19