Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2782673..2783289 Replicon chromosome
Accession NZ_CP060592
Organism Rouxiella badensis strain C173

Toxin (Protein)


Gene name Hha Uniprot ID A0A1X0WJL4
Locus tag H2866_RS12760 Protein ID WP_026110585.1
Coordinates 2782673..2782876 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1X0WJ85
Locus tag H2866_RS12765 Protein ID WP_017492280.1
Coordinates 2782921..2783289 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2866_RS12745 2778223..2779572 - 1350 WP_192503402.1 NCS2 family permease -
H2866_RS12750 2779637..2781424 - 1788 WP_192503403.1 amidohydrolase family protein -
H2866_RS12755 2781568..2782494 + 927 WP_017492278.1 LysR family transcriptional regulator -
H2866_RS12760 2782673..2782876 - 204 WP_026110585.1 hemolysin expression modulator Hha Toxin
H2866_RS12765 2782921..2783289 - 369 WP_017492280.1 Hha toxicity modulator TomB Antitoxin
H2866_RS12770 2783490..2783843 - 354 WP_017492281.1 hypothetical protein -
H2866_RS12775 2784273..2785010 + 738 WP_017492282.1 ABC transporter ATP-binding protein -
H2866_RS12780 2785007..2785864 + 858 WP_017492283.1 metal ABC transporter permease -
H2866_RS12785 2785901..2786779 + 879 WP_017492284.1 metal ABC transporter substrate-binding protein -
H2866_RS12790 2786914..2787054 - 141 WP_009639085.1 type B 50S ribosomal protein L36 -
H2866_RS12795 2787075..2787329 - 255 WP_009639086.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8115.43 Da        Isoelectric Point: 7.9892

>T170509 WP_026110585.1 NZ_CP060592:c2782876-2782673 [Rouxiella badensis]
MNKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELELFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 204 bp

>T170509 NZ_CP077421:c3147299-3146985 [Pectobacterium polaris]
ATGCAATTCACTGTATACGGTAATACCGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
ACAATTGAATCGTCGGATAGTGATCCCATTGCTCCCTATTGAAAAGTATCCAGCAGGCCGCCGACCGGATCGCCTTGTCC
CCGTCGTCATGCTGACGGACGGCAAAGAATACGCCGTAATGACCCACGAGCTGGCAAGTATCCCTGTCCAGGCCCTGGGT
GCGGTGTTTTGTGATGCTTCGCAGTACCGTTCTCAGATAAAGGCTGCAATAGACTTCCTCATCGACGGGTTCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14280.97 Da        Isoelectric Point: 4.5844

>AT170509 WP_017492280.1 NZ_CP060592:c2783289-2782921 [Rouxiella badensis]
MDEYSPKRHDIAQLRFLNESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDETNLSDLVEEYL
DDTYTLFSNYGINDSDLRQWQKTKKRLFRMFSGDYVCTLMKT

Download         Length: 369 bp

>AT170509 NZ_CP077421:c3147538-3147302 [Pectobacterium polaris]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGACGGTGGAGCGTGCCTTACTGGTAAGAGCGCGTGAAGCGGG
TATTAACCTAAGTGCTACTCTGTCAACCGCACTGGATGCGGAGCTTCGCCGTCATGAAGCGAAAATATGGCAGGAAGAAA
ACAGGGAGGCTATCGACGCATTAAATCGTTTTCATGATGAAAACGGCTGTTTCAGTGATGAATACAGGACGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X0WJL4

Antitoxin

Source ID Structure
AlphaFold DB A0A1X0WJ85

References