Detailed information of TA system TA170507

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 2279105..2279827
• Replicon: chromosome
• Accession: NZ_CP060592
• Organism: Rouxiella badensis strain C173

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: H2866_RS10545
• Protein ID: WP_192504365.1
• Coordinates: 2279507..2279827 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: H2866_RS10540
• Protein ID: WP_192504364.1
• Coordinates: 2279105..2279440 (+)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H2866_RS10515	2274238..2275376	+	1139	Protein_2032	IS3 family transposase	-
H2866_RS10520	2275701..2276924	-	1224	WP_192504362.1	XRE family transcriptional regulator	-
H2866_RS10525	2276921..2277562	-	642	WP_192504363.1	hypothetical protein	-
H2866_RS10530	2277891..2278394	+	504	WP_192504439.1	hypothetical protein	-
H2866_RS10535	2278663..2279091	+	429	WP_192504440.1	DNA repair protein RadC	-
H2866_RS10540	2279105..2279440	+	336	WP_192504364.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
H2866_RS10545	2279507..2279827	+	321	WP_192504365.1	TA system toxin CbtA family protein	Toxin
H2866_RS10550	2279941..2280774	+	834	WP_192504366.1	DUF4942 domain-containing protein	-
H2866_RS10555	2280871..2281119	+	249	WP_192504367.1	ribbon-helix-helix domain-containing protein	-
H2866_RS10560	2281123..2281398	+	276	WP_192504368.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H2866_RS10565	2281695..2282183	-	489	Protein_2042	transposase family protein	-
H2866_RS10570	2282180..2282296	-	117	WP_192504369.1	transposase	-
H2866_RS10575	2282414..2283034	-	621	WP_192504370.1	hypothetical protein	-
H2866_RS10580	2283293..2283370	+	78	WP_081601429.1	hypothetical protein	-
H2866_RS10585	2283604..2283969	+	366	WP_165429822.1	integrase core domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2271930..2283034	11104

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (11-105)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12064.75 Da
• Isoelectric Point: 5.0356

>T170507 WP_192504365.1 NZ_CP060592:2279507-2279827 [Rouxiella badensis]
MQILSVPATVPVASRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDATIEEHIDAGITLADAVNFLVERYELVRTDRKGF
TWQEQTPFLTVTDILRAKRATGLMNT

Nucleotide

• Length: 321 bp

>T170507 NZ_CP077421:c211542-211363 [Pectobacterium polaris]
ATGGATAGCAGGACGTTAATAGCAGAAATCAAGGCCGATGGGTGGGAACTGATAAGAGTGAACGGAAGCCACCACCATTT
TATGCACCCTAGCAAATCGGGGTTAGTCACAATCCCCCACCCTAAGAAAGATTTACCGATAGGTACGGTAAAAAGCATCA
GGAAACAGGCAGGAATATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12538.26 Da
• Isoelectric Point: 6.6258

>AT170507 WP_192504364.1 NZ_CP060592:2279105-2279440 [Rouxiella badensis]
MNKDATQTWGLKRDITPCFGARLVQDGHRLNFLADRAGFTGSFSEMQARQLDEAFPHFVAHMELMLLSGELNPRCAHCVT
LYRNELTCEADTLGSHGYVYIAIYPSNKLKD

Nucleotide

• Length: 336 bp

>AT170507 NZ_CP077421:c211335-210925 [Pectobacterium polaris]
ATGTTTTATCCGATTGCAATTGAAGCAGGCGACGATACCCACGCATACGGTGTAACCGTGCCAGATCTACCGGGCTGTTT
TTCTGCAGGCGATACGCTAGACGATGCTATCGCGAATGCTAAAGAGGCGATTACCGGACATATCGAATTGCTGATCGAGA
TGGGTCAGGATATTCCCGCCGTGTCGTCAGTAGGCCAATTGGCAAAAAACGCAGAATACGCTGGGTACACATGGGCGGTT
GTTGATATCGACGTGACACGTTTAATGGGCGGTTCAGAAAAAATTAACGTCACACTGCCTAAGTCGCTGATTGACCGCAT
CGATCGTTGCGTAGCGAGTAATCCAGAATTTAAAAGTCGCTCAGGTTTTCTCGCACAGGCAGCATTAGAACGAATATCGT
CTGCTCGGTAA