Detailed information of TA system TA170505

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/PIN-RelB
• Location: 1394090..1394943
• Replicon: chromosome
• Accession: NZ_CP060588
• Organism: Bifidobacterium longum strain LC67

Toxin (Protein)

• Gene name: relE
• Uniprot ID: V6XWY1
• Locus tag: H4O80_RS06070
• Protein ID: WP_007054468.1
• Coordinates: 1394090..1394581 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V6XX41
• Locus tag: H4O80_RS06075
• Protein ID: WP_008783109.1
• Coordinates: 1394581..1394943 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H4O80_RS06050	1389944..1390843	-	900	WP_187400775.1	Bax inhibitor-1/YccA family protein	-
H4O80_RS06055	1391012..1391152	+	141	Protein_1169	response regulator transcription factor	-
H4O80_RS06060	1391193..1391834	+	642	WP_029679476.1	GNAT family N-acetyltransferase	-
H4O80_RS06065	1391923..1394028	+	2106	WP_187400776.1	DUF262 domain-containing protein	-
H4O80_RS06070	1394090..1394581	-	492	WP_007054468.1	PIN domain-containing protein	Toxin
H4O80_RS06075	1394581..1394943	-	363	WP_008783109.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
H4O80_RS06080	1395089..1397788	-	2700	WP_060620904.1	aconitate hydratase AcnA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-141)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-53)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 18328.91 Da
• Isoelectric Point: 4.5590

>T170505 WP_007054468.1 NZ_CP060588:c1394581-1394090 [Bifidobacterium longum]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNITLLCASLSLKDIAYLSSSAIRREFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Nucleotide

• Length: 492 bp

>T170505 NZ_CP077421:c28900-28529 [Pectobacterium polaris]
TTGGCATGGGAAATAGTCACACGGGCGCTATTCGATATTTGGTTTGATGAACAAACCGAAGCGGTACAGGAAGAGGTTTT
GGCACACCTCGCTATACTCGAAGAGGATGGCCCACAGCTAGGACGACCACAGGTTGATCAGATTAAAGGCTCAAAATACA
AAAATATGAAGGAGCTTCGGGTTCAGGTTGGCGGCCACCCATATCGAACATTCTTCGCGTTTGACCGGACACGTAAGGCG
ATTATTTTATGTGCGGGAGATAAGAAAGGCGAAGATGAAAAGTTGTTCTACGAACGTATGATTAAGATCGCAGACGCTGA
GTTTACATCGCATCTGATATCACCGGAGGCAAAAGAAGATGGCAACGCTTAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13974.03 Da
• Isoelectric Point: 5.0733

>AT170505 WP_008783109.1 NZ_CP060588:c1394943-1394581 [Bifidobacterium longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDAYYNMKRAD

Nucleotide

• Length: 363 bp

>AT170505 NZ_CP077421:c28542-28243 [Pectobacterium polaris]
ATGGCAACGCTTAAAGAAATGATGGCTAAACGTTCACCAGAGAGCCGCGCCCGCATTGAAGCGCGCACGGCTGAGATCCG
TCAGGAAATCACTTTAGCGAAACTACGCGAAGAGCTGAACATGTCGCAGACTCAGCTTGCGTTAGCTCTGGGCGTCAAAC
AGCCATCCATTGTTAAGATGGAAAAGGTCGAAAATGACCCAAAACTATCAACGCTAAAACGCTATGTCACTGCCCTAGGC
GGCGAGCTTACGCTAGATGTGACCTTGCCTGATGGTAAGCGTATCGCGCTTACTTTGTAA

Structures

Toxin

• AlphaFold DB: V6XWY1

Antitoxin

• AlphaFold DB: V6XX41