Detailed information of TA system TA170504

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 771635..772284
• Replicon: chromosome
• Accession: NZ_CP060587
• Organism: Aeromicrobium sp. zg-629

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H9L21_RS03855
• Protein ID: WP_187411771.1
• Coordinates: 771865..772284 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H9L21_RS03850
• Protein ID: WP_154595610.1
• Coordinates: 771635..771868 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9L21_RS03830	767742..769361	+	1620	WP_154595613.1	ATP-binding cassette domain-containing protein	-
H9L21_RS03835	769420..769584	+	165	Protein_742	ATP-binding cassette domain-containing protein	-
H9L21_RS03840	770231..770677	+	447	WP_154595612.1	DUF2510 domain-containing protein	-
H9L21_RS03845	770834..771559	+	726	WP_154595611.1	DinB family protein	-
H9L21_RS03850	771635..771868	+	234	WP_154595610.1	Arc family DNA-binding protein	Antitoxin
H9L21_RS03855	771865..772284	+	420	WP_187411771.1	type II toxin-antitoxin system VapC family toxin	Toxin
H9L21_RS03860	772402..772989	-	588	WP_154595609.1	CGNR zinc finger domain-containing protein	-
H9L21_RS03865	773044..774339	+	1296	WP_187411772.1	MFS transporter	-
H9L21_RS03870	774407..776488	-	2082	WP_154595607.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• Arc-like DNA binding domain (12-42)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15117.21 Da
• Isoelectric Point: 4.4109

>T170504 WP_187411771.1 NZ_CP060587:771865-772284 [Aeromicrobium sp. zg-629]
VIVLDTNVISEIFRPQPEPRVLAWLESLTDDVAITSITLAELLAEVRGLPEGRRKTDLSAAIHAAIQPYRDTRSLLAFDA
DAADEYAEVFVLRERAGLPISMADAQIAAICRANRAVCATRNVKDFDATGVEVVNPWGG

Nucleotide

• Length: 420 bp

>T170504 NZ_CP077418:311432-311731 [Rhodococcus qingshengii]
ATGCGACCAATTCACGAAGCCGACCTCGACACAGTCCGCCCGGTCCTCGTACTCACCCGAGAGGTGGTCCGTCCACACCT
CGGGACCGTCACGGTAGCGCCCATCACCGACGAGATCCGAGGACTGTCCACTGAGGTGTCCGTCAGTGCCGCGAACGGAC
TATCCGCCGACGCGGTGGTCAGTTGCGATCACATCACCACCATTCCCGTCAGTGCACTCGGCAACGTCATCGGTTATCTT
CTGCCAGCACAAGAAGAATCACTGTCCATAGCCGTGCGCGCCGCATTCGATCTCGAATGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8150.20 Da
• Isoelectric Point: 5.0760

>AT170504 WP_154595610.1 NZ_CP060587:771635-771868 [Aeromicrobium sp. zg-629]
MASIIVRGLDDSVKQRLAAQAEEHGRSMEAEVRDILTRAASRPHVGLALLEAARAVGGVEDLAIPERSDAARGVDFG

Nucleotide

• Length: 234 bp

>AT170504 NZ_CP077418:311196-311432 [Rhodococcus qingshengii]
ATGAGCACGCAGATCGCGGTACGACTACCGGACGAGATCGTGGCATTTCTCGACGACGAAATCAGGGAACATCGCGCCAC
CTCGCGAGCCTCGGTAGTGTTGCGCGCTCTCGAGCGCGAACGTCGCCGTCAGATTGCCGCACGTGACGCGGAGATTCTCG
CGAACGCCACACCCGAACATGACCTGAGTTCTCTCGCTCACCACGCCGCCAATCCGCAGTCAACCGGCTTGAGCTGA