Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2008610..2009087 Replicon chromosome
Accession NZ_CP060584
Organism Staphylococcus aureus strain WH52

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag H9M95_RS09855 Protein ID WP_000052078.1
Coordinates 2008899..2009087 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag H9M95_RS09850 Protein ID WP_001059690.1
Coordinates 2008610..2008870 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9M95_RS09815 2004003..2004719 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
H9M95_RS09820 2004867..2005289 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
H9M95_RS09825 2005688..2006182 + 495 WP_048665416.1 GNAT family N-acetyltransferase -
H9M95_RS09830 2006337..2006954 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
H9M95_RS09835 2007027..2007608 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
H9M95_RS09840 2007833..2008069 + 237 WP_000368687.1 hypothetical protein -
H9M95_RS09845 2008066..2008269 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
H9M95_RS09850 2008610..2008870 + 261 WP_001059690.1 hypothetical protein Antitoxin
H9M95_RS09855 2008899..2009087 + 189 WP_000052078.1 hypothetical protein Toxin
H9M95_RS09860 2009275..2009844 + 570 WP_001106654.1 hypothetical protein -
H9M95_RS09865 2009932..2010216 + 285 WP_001004395.1 hypothetical protein -
H9M95_RS09870 2010278..2010496 + 219 WP_000005886.1 hypothetical protein -
H9M95_RS09875 2010992..2011192 - 201 WP_001059082.1 cold-shock protein -
H9M95_RS09880 2011549..2012235 - 687 WP_001548082.1 thermonuclease family protein -
H9M95_RS09885 2012577..2013047 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T170503 WP_000052078.1 NZ_CP060584:2008899-2009087 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T170503 NZ_CP077412:58156-58572 [Enterobacter asburiae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACCGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTTCTGG
AAGACTGGGTTAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT170503 WP_001059690.1 NZ_CP060584:2008610-2008870 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT170503 NZ_CP077412:57929-58159 [Enterobacter asburiae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References