Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 829656..830185 Replicon chromosome
Accession NZ_CP060584
Organism Staphylococcus aureus strain WH52

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag H9M95_RS04010 Protein ID WP_001103933.1
Coordinates 829868..830185 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag H9M95_RS04005 Protein ID WP_001058487.1
Coordinates 829656..829865 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9M95_RS03970 824887..825171 + 285 WP_000917289.1 co-chaperone GroES -
H9M95_RS03975 825247..826863 + 1617 WP_000240645.1 chaperonin GroEL -
H9M95_RS03980 826932..828104 - 1173 WP_000179353.1 site-specific integrase -
H9M95_RS03985 828118..828840 - 723 WP_000672427.1 helix-turn-helix domain-containing protein -
H9M95_RS03990 828993..829199 + 207 WP_000794657.1 helix-turn-helix transcriptional regulator -
H9M95_RS03995 829203..829520 + 318 WP_000481968.1 helix-turn-helix domain-containing protein -
H9M95_RS04000 829517..829663 + 147 WP_000708434.1 hypothetical protein -
H9M95_RS04005 829656..829865 + 210 WP_001058487.1 hypothetical protein Antitoxin
H9M95_RS04010 829868..830185 + 318 WP_001103933.1 DUF1474 family protein Toxin
H9M95_RS04015 830252..831121 + 870 WP_001002699.1 primase alpha helix C-terminal domain-containing protein -
H9M95_RS04020 831138..832607 + 1470 WP_117196693.1 virulence-associated E family protein -
H9M95_RS04025 832893..833255 + 363 WP_001039169.1 hypothetical protein -
H9M95_RS04030 833257..833541 + 285 WP_000998179.1 hypothetical protein -
H9M95_RS04035 833538..834179 + 642 WP_001019811.1 hypothetical protein -
H9M95_RS04040 834715..835056 + 342 WP_001190614.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 822012..850249 28237


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T170499 WP_001103933.1 NZ_CP060584:829868-830185 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T170499 NZ_CP077411:c3964189-3963878 [Enterobacter asburiae]
ATGCTATTCATTGAAACGGATATTTTCACAGAAGACGTCAAAACGTTACTGGATGACGACGAATATCATAGGTTCCAGGT
ATTCCTGGCTCCGCAACCGGAGTTCGGCGATCTTATCCAGAATACGGGAGGCCTGCGAAAGATTCGCTGGCTTGCTGGCG
GTAAGGGGAAGCGTGGTGGAGTCAGAGTCATCTATTTTCATCGTACGCGTGAGTATGAAATTAGACTGCTGCTCATCTAT
CGCAAAGGAATCAAAGATGACCTTTCTGCAAGTGAGAAAGCCATTCTGAAAAAGATGATTGAGAGGTGGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT170499 WP_001058487.1 NZ_CP060584:829656-829865 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT170499 NZ_CP077411:c3963877-3963587 [Enterobacter asburiae]
ATGGATAAGGCGCTATTTGAGCGATTAACCAAAAGCATGGCGCAAATGAACGAAATTGCCGAGGGCAAACGTGAGCCATC
GCGCACCTTTCAAATCGACGCGATAAAAATTAAAGAAATTCGTCAAGCGTCCGGGCTATCGCAGAGTAAATTCGCGAATT
TAATTTCTGTTAGTGTCGATACACTGCGTAACTGGGAACAAGGCAGGCGCTCACCTACAGGTCCGGCTAAAGCGCTGCTG
CGGGCTATTGCCAACGATCCTCAACATGTTATCCCTGCACTTTCGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References