Detailed information of TA system TA170488

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 1884710..1885512
• Replicon: chromosome
• Accession: NZ_CP060528
• Organism: Staphylococcus epidermidis strain LM087

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: ATM22_RS08985
• Protein ID: WP_002493409.1
• Coordinates: 1885051..1885512 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: ATM22_RS08980
• Protein ID: WP_002493408.1
• Coordinates: 1884710..1885039 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ATM22_RS08945	1880601..1882553	-	1953	WP_002493404.1	AAA family ATPase	-
ATM22_RS08950	1882622..1882798	-	177	WP_002493405.1	hypothetical protein	-
ATM22_RS08955	1882864..1883073	-	210	WP_001830281.1	hypothetical protein	-
ATM22_RS08960	1883086..1883805	-	720	WP_002493406.1	phage repressor protein	-
ATM22_RS08965	1883855..1884094	+	240	WP_002475580.1	hypothetical protein	-
ATM22_RS08970	1884084..1884263	-	180	WP_002475588.1	hypothetical protein	-
ATM22_RS08975	1884277..1884516	-	240	WP_002493407.1	helix-turn-helix domain-containing protein	-
ATM22_RS08980	1884710..1885039	+	330	WP_002493408.1	helix-turn-helix domain-containing protein	Antitoxin
ATM22_RS08985	1885051..1885512	+	462	WP_002493409.1	ImmA/IrrE family metallo-endopeptidase	Toxin
ATM22_RS08990	1885544..1886050	+	507	WP_033862683.1	hypothetical protein	-
ATM22_RS08995	1886052..1886633	+	582	WP_002493411.1	hypothetical protein	-
ATM22_RS09000	1886696..1887745	+	1050	WP_002493412.1	site-specific integrase	-
ATM22_RS09015	1888147..1888722	-	576	WP_002493413.1	competence protein ComK	-
ATM22_RS09020	1888937..1889155	+	219	WP_001829292.1	IDEAL domain-containing protein	-
ATM22_RS09025	1889233..1890219	-	987	WP_002493414.1	lipoate--protein ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1842002..1887745	45743

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• IrrE N-terminal-like domain (28-120)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18183.68 Da
• Isoelectric Point: 5.9380

>T170488 WP_002493409.1 NZ_CP060528:1885051-1885512 [Staphylococcus epidermidis]
MGLYEEICIDNDMVEIKETNKLPSFQSGFYMNGTVYIKSDLSEKEKIKVLYEELAHHKLTYGNILDQSKFNNRKFENYAR
RHGYEAALPLRIIVEAHNYGVSNLYELAEYVQLSEEYIAEILKHYKNKYGIGTHYEEYLITFDPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T170488 NZ_CP077407:c4241754-4241536 [Enterobacter roggenkampii]
ATGTCTGATAAACCACTCACTAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACCCTCGAACGCGT
GATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCCGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAGC
TGACCATGAATAAGTTGTATGACAAAATCCCTACTTCTGTATGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12667.26 Da
• Isoelectric Point: 4.9783

>AT170488 WP_002493408.1 NZ_CP060528:1884710-1885039 [Staphylococcus epidermidis]
MRTNDEIITIIKTTLKEQNMSLSELARRVGMAKSAVSRYLNLTREFPLNRAEDFANALHISTEYLLGFNGSEQTRQQDTM
AAHFDKEGLTEEEIEEVNKFIEWVKNRDK

Nucleotide

• Length: 330 bp

>AT170488 NZ_CP077407:c4242156-4241782 [Enterobacter roggenkampii]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAACCTTGATGAAAGCAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGTAGTTACGGCATTAACGCCCAGGATTTGCAAAAATGGCGTAAATCGGGAAACCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTTAGCCTTTCCTGTTAA