Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 983827..984632 Replicon chromosome
Accession NZ_CP060528
Organism Staphylococcus epidermidis strain LM087

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag ATM22_RS04780 Protein ID WP_002493979.1
Coordinates 984450..984632 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag ATM22_RS04775 Protein ID WP_002493980.1
Coordinates 983827..984426 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATM22_RS04750 979036..980493 + 1458 WP_002493984.1 ABC transporter substrate-binding protein/permease -
ATM22_RS04755 980486..981208 + 723 WP_002493983.1 amino acid ABC transporter ATP-binding protein -
ATM22_RS04760 981704..981859 + 156 WP_002493982.1 hypothetical protein -
ATM22_RS04765 982072..983202 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
ATM22_RS04770 983199..983669 + 471 WP_002493981.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
ATM22_RS04775 983827..984426 + 600 WP_002493980.1 hypothetical protein Antitoxin
ATM22_RS04780 984450..984632 + 183 WP_002493979.1 hypothetical protein Toxin
ATM22_RS04785 984784..985188 + 405 WP_002493978.1 hypothetical protein -
ATM22_RS04790 985374..986759 + 1386 WP_002493977.1 class II fumarate hydratase -
ATM22_RS04795 987120..987944 - 825 WP_002493976.1 RluA family pseudouridine synthase -
ATM22_RS04800 988103..989236 + 1134 WP_002493975.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 981704..981859 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7070.63 Da        Isoelectric Point: 4.3016

>T170487 WP_002493979.1 NZ_CP060528:984450-984632 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDFKNSK

Download         Length: 183 bp

>T170487 NZ_CP077407:3782626-3782913 [Enterobacter roggenkampii]
ATGCCAACGGAGTATGAGTGGGATAGCAATAAGGCGAAAAGTAACCTGCAAAAACATGGCATACGCTTTGAGGATGCGGT
TATGGTTTTTGACGATCCTTATCATTTGTCTGTTCAGGATCGCTATGAGAACGGTGAATTTCGCTGGCAAACCATCGGCC
TTGTGCAAGGTCTTCTTGTTATTCTGGTCGCACATACGGTACGTTTTGAAAGCGGAGGAGAAATCATCCGTATCATTAGC
GCACGAAAGGCGGACCGCAAAGAGAGGAGCCGTTATGAGCATCGTTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22670.59 Da        Isoelectric Point: 4.8668

>AT170487 WP_002493980.1 NZ_CP060528:983827-984426 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEQAPVFDELKKNVENHAVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT170487 NZ_CP077407:3782900-3783202 [Enterobacter roggenkampii]
ATGAGCATCGTTAAACATAAACGCGGTAGTGCGCCTGAGGTAAGCGCTCGTCGTGAGGCTGAGCTCAAAGCATTAGCTGA
AAAACCAGAAGCAGAGATTGATTACAGCGATATCCCTGCTACGGACGATGAACAGTGGTCAGGTGCGGTGCGAGGAAAGT
TTTATCGTCCACTCAAAACTCAGGCATCTGTACGCATTGACGCCGATGTGATGGAGTGGCTTAAACGGCCTGGGAAAGGT
TATCAGACGCGGCTCAATGCCATTTTGCGTGAAGCAATGCTGCGCGATCAAAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References