Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 821466..821995 Replicon chromosome
Accession NZ_CP060528
Organism Staphylococcus epidermidis strain LM087

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag ATM22_RS03820 Protein ID WP_001829891.1
Coordinates 821633..821995 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag ATM22_RS03815 Protein ID WP_001829931.1
Coordinates 821466..821636 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATM22_RS03790 817290..817769 + 480 WP_002494210.1 PH domain-containing protein -
ATM22_RS03795 817762..819267 + 1506 WP_002494209.1 PH domain-containing protein -
ATM22_RS03800 819254..819763 + 510 WP_002494208.1 PH domain-containing protein -
ATM22_RS03805 819811..820164 + 354 WP_001829915.1 holo-ACP synthase -
ATM22_RS03810 820231..821379 + 1149 WP_002494207.1 alanine racemase -
ATM22_RS03815 821466..821636 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
ATM22_RS03820 821633..821995 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ATM22_RS03825 822340..823341 + 1002 WP_002494206.1 PP2C family protein-serine/threonine phosphatase -
ATM22_RS03830 823441..823767 + 327 WP_001829952.1 anti-sigma factor antagonist -
ATM22_RS03835 823769..824248 + 480 WP_002474646.1 anti-sigma B factor RsbW -
ATM22_RS03840 824223..824993 + 771 WP_002474636.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T170486 WP_001829891.1 NZ_CP060528:821633-821995 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T170486 NZ_CP077407:c3446213-3445896 [Enterobacter roggenkampii]
ATGAAGGAGATTGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGCTCGACGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTAGCGGGCGACGTTAAACCCGTGGGAGAAGGTATAAGTGAGCTAAGGATCC
ACTTTGGTCCGGGCTACAGGATCTATTTTAAAGACCAGGGCAATTACATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTGATGGAAAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGAATGAGCATGCATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT170486 WP_001829931.1 NZ_CP060528:821466-821636 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT170486 NZ_CP077407:c3445903-3445616 [Enterobacter roggenkampii]
ATGCATAAATTAACACCTTACGATCCCGCCAACGCGTTGGTGGATGACGAGGAAATCGCCGTGTTTATCGCTGATGCACT
AGAAACAGGCGACTCGACATATATCGCTAAAGCCCTTGGTGTTGTCGCGCGAGCCAAAGGCATGTCGAACATTTCACAGC
AAACCGGTTTATCACGTGAGCAGCTTTATCGGTCATTCAGTGATAAAGGAAACCCAACGCTCAAAACCACGCTCGCGGTC
ATGAAAGCATTGGGTTTTGGGCTAACACTCAAACACGCCGGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References