Detailed information of TA system TA170485

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 810281..810790
• Replicon: chromosome
• Accession: NZ_CP060528
• Organism: Staphylococcus epidermidis strain LM087

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: ATM22_RS03760
• Protein ID: WP_002494211.1
• Coordinates: 810587..810790 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: Q5HMD4
• Locus tag: ATM22_RS03755
• Protein ID: WP_001829893.1
• Coordinates: 810281..810574 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ATM22_RS03730	805289..806077	+	789	WP_002494215.1	hydroxyethylthiazole kinase	-
ATM22_RS03735	806083..806721	+	639	WP_032603839.1	thiamine phosphate synthase	-
ATM22_RS03740	806810..807682	+	873	WP_002458703.1	membrane protein insertase YidC	-
ATM22_RS03745	807788..808441	-	654	WP_002494213.1	HD domain-containing protein	-
ATM22_RS03750	808623..810107	-	1485	WP_002494212.1	cardiolipin synthase	-
ATM22_RS03755	810281..810574	+	294	WP_001829893.1	copper-sensing transcriptional repressor CsoR	Antitoxin
ATM22_RS03760	810587..810790	+	204	WP_002494211.1	hypothetical protein	Toxin
ATM22_RS03765	810933..811070	+	138	WP_001829949.1	hypothetical protein	-
ATM22_RS03770	811169..812380	-	1212	WP_002474606.1	rod shape-determining protein RodA	-
ATM22_RS03775	812771..813844	+	1074	WP_001832735.1	D-alanine--D-alanine ligase	-
ATM22_RS03780	813856..815211	+	1356	WP_002494890.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (4-95)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7785.00 Da
• Isoelectric Point: 6.4524

>T170485 WP_002494211.1 NZ_CP060528:810587-810790 [Staphylococcus epidermidis]
MKKGLIHVSGIKTTEQAKQLKDHLSKMIGINCVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Nucleotide

• Length: 204 bp

>T170485 NZ_CP077407:c3445903-3445616 [Enterobacter roggenkampii]
ATGCATAAATTAACACCTTACGATCCCGCCAACGCGTTGGTGGATGACGAGGAAATCGCCGTGTTTATCGCTGATGCACT
AGAAACAGGCGACTCGACATATATCGCTAAAGCCCTTGGTGTTGTCGCGCGAGCCAAAGGCATGTCGAACATTTCACAGC
AAACCGGTTTATCACGTGAGCAGCTTTATCGGTCATTCAGTGATAAAGGAAACCCAACGCTCAAAACCACGCTCGCGGTC
ATGAAAGCATTGGGTTTTGGGCTAACACTCAAACACGCCGGGGATTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11070.65 Da
• Isoelectric Point: 5.5778

>AT170485 WP_001829893.1 NZ_CP060528:810281-810574 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT170485 NZ_CP077407:c3446213-3445896 [Enterobacter roggenkampii]
ATGAAGGAGATTGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGCTCGACGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTAGCGGGCGACGTTAAACCCGTGGGAGAAGGTATAAGTGAGCTAAGGATCC
ACTTTGGTCCGGGCTACAGGATCTATTTTAAAGACCAGGGCAATTACATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTGATGGAAAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGAATGAGCATGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A0N1EPA7