Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 6768..7360 Replicon plasmid pS8250-2
Accession NZ_CP060524
Organism Salmonella enterica strain SLR1_8250

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag H9L29_RS23070 Protein ID WP_000520549.1
Coordinates 6768..7016 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag H9L29_RS23075 Protein ID WP_000681613.1
Coordinates 7013..7360 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9L29_RS23040 3645..4160 + 516 Protein_3 DnaJ domain-containing protein -
H9L29_RS23045 4265..4807 + 543 WP_001083906.1 hypothetical protein -
H9L29_RS23050 4804..5055 + 252 WP_001230707.1 hypothetical protein -
H9L29_RS23055 5042..5269 + 228 WP_000801440.1 hypothetical protein -
H9L29_RS23060 5723..6022 + 300 WP_000650309.1 hypothetical protein -
H9L29_RS23065 6113..6463 + 351 WP_000854259.1 hypothetical protein -
H9L29_RS23070 6768..7016 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
H9L29_RS23075 7013..7360 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H9L29_RS23080 7721..8224 + 504 WP_000781813.1 hypothetical protein -
H9L29_RS23085 8228..9457 + 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
H9L29_RS23090 9534..9827 + 294 WP_060598542.1 LuxR family transcriptional regulator -
H9L29_RS23095 9824..10039 + 216 WP_000760375.1 EexN family lipoprotein -
H9L29_RS23100 10395..11015 + 621 WP_000157549.1 lytic transglycosylase domain-containing protein -
H9L29_RS23105 11083..11355 + 273 WP_001328551.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33310 33310


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 10656.47 Da        Isoelectric Point: 12.7138

>T170484 WP_000520549.1 NZ_CP060524:6768-7016 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKK

Download         Length: 249 bp

>T170484 NZ_CP077407:3237415-3237813 [Enterobacter roggenkampii]
ATGAGACATATGCTGGATACGAATATTGTGAGTCACTTGTTTAAACGACACCCGGAGGTTGTAAGCAGAATGACATGTCT
GGCGCCGGGTGACGTTTGTATCTCAAGCATAACCGAAGCGGAATTGCTGTATGGTGCTGACAAGAAGAAAAGCAGTAGAT
TGAAAGAAACAATCCGGGAGTTTCTCAATACCATCACGATTTGCGACTGGGACAGCGACGCCGCAGCAACGTACGGTGAA
CTCCGTGCAACCCTGGAAAAGAAAGGGAAAGTGATGGGGGATCTCGATCAACTGATCGCTGCACATGCTATCAGTCGGGG
AACAACGATCGTTACTAACGATCGTGCATTCAGAATGGTGCAGGAGCTTGCCGTCGAGGACTGGACGACAACGTTGTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 14886.21 Da        Isoelectric Point: 12.8607

>AT170484 WP_000681613.1 NZ_CP060524:7013-7360 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 348 bp

>AT170484 NZ_CP077407:3237152-3237418 [Enterobacter roggenkampii]
ATGGAACGCACAGCAAAACTATTCAAAAAGGGTCAGAATCAGGCCGTTATGCTGCCTGCTGAATTCGCGTTTAATGCGGA
GAGCGTCTACATCCGACGGGATGAGGAGGGGAATGTCGTTTTGGCGGCAAAACCTGTTCTAATAAAGAGCTGGGATAATT
TTCTCCGCATGCTGGCAGAAACGGACGTACCAGATACGTTTTTGAGCAAGGAGGAACGCAATCAGAGTGTTACGACAAGA
GACCCTCTGGATGGAGCATGCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References