Detailed information of TA system TA170481

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsxAB/MqsA(antitoxin)
• Location: 7056..7549
• Replicon: plasmid pS7627-2
• Accession: NZ_CP060519
• Organism: Salmonella enterica strain SLR1_7627

Toxin (Protein)

• Gene name: TsxA
• Uniprot ID: U9Y9W8
• Locus tag: H9L30_RS24105
• Protein ID: WP_001230709.1
• Coordinates: 7056..7310 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: TsxB
• Uniprot ID: U9Y4R8
• Locus tag: H9L30_RS24110
• Protein ID: WP_000151456.1
• Coordinates: 7307..7549 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9L30_RS24070	2628..2789	+	162	WP_106479314.1	type I toxin-antitoxin system Hok family toxin	-
H9L30_RS24075	2939..3535	+	597	WP_000125165.1	hypothetical protein	-
H9L30_RS24080	3553..3837	-	285	WP_001162371.1	hypothetical protein	-
H9L30_RS24085	3911..4576	-	666	WP_000532148.1	P-loop NTPase	-
H9L30_RS24090	5165..5494	+	330	WP_000855119.1	hypothetical protein	-
H9L30_RS24095	5898..6413	+	516	WP_001025393.1	J domain-containing protein	-
H9L30_RS24100	6517..7059	+	543	WP_001083904.1	hypothetical protein	-
H9L30_RS24105	7056..7310	+	255	WP_001230709.1	hypothetical protein	Toxin
H9L30_RS24110	7307..7549	+	243	WP_000151456.1	hypothetical protein	Antitoxin
H9L30_RS24115	8120..8413	+	294	WP_000673428.1	hypothetical protein	-
H9L30_RS24120	8830..9012	-	183	WP_024135751.1	hypothetical protein	-
H9L30_RS24125	9570..9752	+	183	WP_000833470.1	type II toxin-antitoxin system HicA family toxin	-
H9L30_RS24130	9777..10214	+	438	WP_000466318.1	type II toxin-antitoxin system HicB family antitoxin	-
H9L30_RS24135	10345..10665	-	321	WP_001401701.1	hypothetical protein	-
H9L30_RS24140	10662..11177	-	516	WP_001229210.1	hypothetical protein	-
H9L30_RS24145	11179..11382	-	204	WP_000224735.1	hypothetical protein	-
H9L30_RS24150	11388..11837	-	450	WP_000206700.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..64443	64443

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-90)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10912.81 Da
• Isoelectric Point: 12.7242

>T170481 WP_001230709.1 NZ_CP060519:7056-7310 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKK

Nucleotide

• Length: 255 bp

>T170481 NZ_CP077406:c3440-3153 [Citrobacter braakii]
ATGGTTAAAACCTATCGCCTTTCGCCACTGGCTGAAGCCGACCTCGAAGAAATCTGGCTCTACACGCTCCGAAACTGGTC
GATAGTACAGGCGGACAACTACCATCACGATCTTGTGGCGACATTCGAAGCGTTGGCGAATGGCATGAAGTTCGGGCTTC
CGTCTGTGCTGCCGGAATACCAGAAGTGTCTGTGTGGCTCTCATGTCGTGTATTTTCTGGACTACACCGATTGCGTGGAC
ATTATTCGTATCCTGCATCAGCGGCAGGATGCAGATCTGCATTTTTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 10400.12 Da
• Isoelectric Point: 12.7030

>AT170481 WP_000151456.1 NZ_CP060519:7307-7549 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
K

Nucleotide

• Length: 243 bp

>AT170481 NZ_CP077406:c3675-3433 [Citrobacter braakii]
ATGCGCCAAAATACATCTGTGGCACTGGGGCCACACTTTTCCAGTTTCGTTGACGCTCAGGTGCAGGGAGGGCGTTATGG
TTCCGCCAGTGATGTTATTCGGGCCGGGTTGCGATTACTGGAGGAGCACGAAGCCCGGGTTAAAGCGCTGCAGGAAGCGC
TGATTGCAGGCCGCGAATCCGGTGAGCCGCGCTCGTTTGACAGTGAAGCCTTTTTGCGCCGGATGCACACGCAGCATGGT
TAA

Structures

Toxin

• AlphaFold DB: A0A3G9H8F0

Antitoxin

• AlphaFold DB: A0A3G9GNF5