Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 48630..49273 Replicon plasmid pS7966-1
Accession NZ_CP060513
Organism Salmonella enterica strain SLR1_7966

Toxin (Protein)


Gene name vagD Uniprot ID A0A5T8FJ24
Locus tag H9L33_RS22805 Protein ID WP_023994137.1
Coordinates 48630..49046 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A5T3Q059
Locus tag H9L33_RS22810 Protein ID WP_023994136.1
Coordinates 49043..49273 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9L33_RS22775 44110..44901 + 792 WP_023994142.1 F4 (K88) fimbria minor subunit FaeH -
H9L33_RS22780 44929..45693 + 765 WP_023994141.1 minor fimbrial protein -
H9L33_RS22785 45896..46486 + 591 WP_023994140.1 hypothetical protein -
H9L33_RS22790 46552..46764 + 213 WP_023994139.1 PefI -
H9L33_RS22795 47025..47186 + 162 WP_001816720.1 hypothetical protein -
H9L33_RS22800 47212..48060 + 849 WP_023994138.1 SdiA-regulated domain-containing protein -
H9L33_RS22805 48630..49046 - 417 WP_023994137.1 type II toxin-antitoxin system VapC family toxin Toxin
H9L33_RS22810 49043..49273 - 231 WP_023994136.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H9L33_RS22815 49897..50115 + 219 WP_023994135.1 type II toxin-antitoxin system antitoxin CcdA -
H9L33_RS22820 50117..50422 + 306 WP_023994134.1 type II toxin-antitoxin system toxin CcdB -
H9L33_RS22825 50424..50714 + 291 WP_023994133.1 hypothetical protein -
H9L33_RS22830 50711..51061 + 351 Protein_58 3'-5' exonuclease -
H9L33_RS22835 51087..51173 + 87 Protein_59 cytoplasmic protein -
H9L33_RS22840 51163..51878 - 716 Protein_60 transposase -
H9L33_RS22845 53160..53696 + 537 WP_023994130.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..254662 254662


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 20475.56 Da        Isoelectric Point: 5.5500

>T170478 WP_023994137.1 NZ_CP060513:c49046-48630 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 417 bp

>T170478 NZ_CP077405:c4586625-4586251 [Citrobacter braakii]
ATGGTCACAGGATCTGCGCTTTTTGATACCAACATCCTCATCGACCTGTTTAGCGGGCGAAGTGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAACGCAATCAGCCTCATTACATGGATGGAGTTGATGGTGGGCGCAAAAAAATATCATCAGG
AATCTCGCACACGCGTTGCGCTAGGCGCTTTTAATGTGATCGGTGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGGCAGGAATATGGGATGAAATTGCCGGATGCCATCATTTTGGCCACTGCGCAGATTCATCGTCTTACACTGGTTACGCG
TAATACCAGGGATTTTGCAGGCATATCCGGCGTGGTCACACCGTATACGTTATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 11350.61 Da        Isoelectric Point: 5.5500

>AT170478 WP_023994136.1 NZ_CP060513:c49273-49043 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 231 bp

>AT170478 NZ_CP077405:c4586867-4586625 [Citrobacter braakii]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGAAGTGATCAAACGTCTTGATGATCTCAAGGT
GCAGCGTAATCTGCCGCGGGCCGAGCTTTTGCGGGAGGCTGTTGAACAGTATCTTGAGAGGCAGGATCAAGCTGAAACGA
CAATTTCACGTGCTCTTGGGCTATGGCAAGGTTGTGAGGAAGATGGCGTTGATTATCAGCGTAAACTCCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8FJ24

Antitoxin

Source ID Structure
AlphaFold DB A0A5T3Q059

References