Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 171153..171678 Replicon plasmid pS7697-1
Accession NZ_CP060509
Organism Salmonella enterica strain SLR1_7697

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag H9L34_RS23335 Protein ID WP_001159871.1
Coordinates 171373..171678 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag H9L34_RS23330 Protein ID WP_000813630.1
Coordinates 171153..171371 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9L34_RS23300 166154..166744 - 591 WP_000194550.1 hypothetical protein -
H9L34_RS23305 166744..166998 - 255 WP_000343103.1 hypothetical protein -
H9L34_RS23310 167350..168351 + 1002 WP_000774875.1 DUF4238 domain-containing protein -
H9L34_RS23315 168527..168871 - 345 WP_000793307.1 hypothetical protein -
H9L34_RS23320 169370..169624 - 255 WP_000678527.1 hypothetical protein -
H9L34_RS23325 169669..170595 - 927 WP_001290416.1 hypothetical protein -
H9L34_RS23330 171153..171371 + 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
H9L34_RS23335 171373..171678 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
H9L34_RS23340 171679..172485 + 807 WP_000016969.1 site-specific integrase -
H9L34_RS23345 172665..173309 + 645 WP_001144036.1 ParA family protein -
H9L34_RS23350 173396..173704 + 309 WP_000030199.1 hypothetical protein -
H9L34_RS23355 174118..175098 + 981 WP_000688514.1 plasmid segregation protein ParM -
H9L34_RS23360 175091..175507 + 417 WP_001278818.1 plasmid partitioning/stability family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..209422 209422


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T170475 WP_001159871.1 NZ_CP060509:171373-171678 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T170475 NZ_CP077405:2883501-2883782 [Citrobacter braakii]
ATGACCTATGAACTCAAATTTGAGCGCCGTGCTAAAAAAGAATGGGATAAATTAGGTCATCCGGTTCGTGAGCAGTTTAA
AAAGAAGCTGGCTGAACGTCTCGAAAACCCACATATCCCTTCAGCGAGGCTTCATGGACGTCCTAATCGCTACAAAATAA
AACTCCGTTCATCTGGCTACAGACTGGTCTATGACGTTATAGACGACAAGCTGGTGTTACTGGTTATCGTTATTGGAAAA
AGAGCGGGTAACGAAGTCTATGAGTTAGCAGACGAAAGGTAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT170475 WP_000813630.1 NZ_CP060509:171153-171371 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT170475 NZ_CP077405:2883260-2883511 [Citrobacter braakii]
ATGACCTATCAGATACTGACCACTATCGCAGCCAGCATAACCGACCTGAAGCGTAACCCTATGGGAACCGTAGCTGACGG
GGAAGGAAACGCCGTGGCAATTCTGAACCGCAACGAACCCGCATTTTACTGTGTACCCCCTGAACTTTACGCCTACTATA
TTGAGCTTGCTGAAGATGCTGAGCTTAATGCTATTGCTGATGAACGCATGAAAGATCCGGACATTGTGAGCGTTAATCTC
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References