Detailed information of TA system TA170473

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 2222085..2222738
• Replicon: chromosome
• Accession: NZ_CP060505
• Organism: Acinetobacter baumannii strain AbCTX5

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: H4B45_RS10505
• Protein ID: WP_000607070.1
• Coordinates: 2222349..2222738 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: H4B45_RS10500
• Protein ID: WP_001288210.1
• Coordinates: 2222085..2222342 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H4B45_RS10480	2217601..2218608	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
H4B45_RS10485	2218627..2219004	+	378	WP_001216380.1	50S ribosomal protein L17	-
H4B45_RS10490	2219185..2220675	+	1491	WP_000415133.1	NAD(P)/FAD-dependent oxidoreductase	-
H4B45_RS10495	2220725..2221897	-	1173	WP_001190546.1	acyl-CoA dehydrogenase family protein	-
H4B45_RS10500	2222085..2222342	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
H4B45_RS10505	2222349..2222738	+	390	WP_000607070.1	hypothetical protein	Toxin
H4B45_RS10510	2223508..2224593	+	1086	WP_000049107.1	hypothetical protein	-
H4B45_RS10515	2224671..2225237	+	567	WP_000651536.1	rhombosortase	-
H4B45_RS10520	2225425..2227620	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15708.02 Da
• Isoelectric Point: 10.3599

>T170473 WP_000607070.1 NZ_CP060505:2222349-2222738 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEDHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T170473 NZ_CP077405:502006-502413 [Citrobacter braakii]
GTGGTCCAGTGGCAATCTGATTTACGCGTTTCATGGCGCGCGCAATGGCTTTCGTTGCTCATTCATGGGCTGGTCGCGGT
ATTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTCTGCTCTCTCTGGTGGTGTTCGATAGCG
TCCGTAGCCAGCGCCGAATCAATGCCTGTCAGGGCGAGATTCGGCTGTTGATGGACGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGACTATTGCTAGCGCACCCTGGATGGTCAAAACAGGCATGATGCTGCGTTTACGTTCCGATGCCGGAAAACGTCA
GCATTTGTGGCTGGCGGCAGACAGTATGGATGACGCGGAGTGGCGGGATTTGCGGCGGTTAATACTGCAACAGGCGAGGC
AGGGATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT170473 WP_001288210.1 NZ_CP060505:2222085-2222342 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT170473 NZ_CP077405:501759-502025 [Citrobacter braakii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGATGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGACT
TATTTAACTGGTTGATGAATCATGGGAAACCGGCTGATGCTCAGCTAGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7