Detailed information of TA system TA170472

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 1695579..1696232
• Replicon: chromosome
• Accession: NZ_CP060504
• Organism: Acinetobacter baumannii strain AbCTX9

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: H4B46_RS08010
• Protein ID: WP_000607070.1
• Coordinates: 1695843..1696232 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: H4B46_RS08005
• Protein ID: WP_001288210.1
• Coordinates: 1695579..1695836 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H4B46_RS07985	1691095..1692102	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
H4B46_RS07990	1692121..1692498	+	378	WP_001216380.1	50S ribosomal protein L17	-
H4B46_RS07995	1692679..1694169	+	1491	WP_000415133.1	NAD(P)/FAD-dependent oxidoreductase	-
H4B46_RS08000	1694219..1695391	-	1173	WP_001190546.1	acyl-CoA dehydrogenase family protein	-
H4B46_RS08005	1695579..1695836	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
H4B46_RS08010	1695843..1696232	+	390	WP_000607070.1	hypothetical protein	Toxin
H4B46_RS08015	1697002..1698087	+	1086	WP_000049107.1	hypothetical protein	-
H4B46_RS08020	1698165..1698731	+	567	WP_000651536.1	rhombosortase	-
H4B46_RS08025	1698919..1701114	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15708.02 Da
• Isoelectric Point: 10.3599

>T170472 WP_000607070.1 NZ_CP060504:1695843-1696232 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEDHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T170472 NZ_CP077405:192085-192405 [Citrobacter braakii]
ATGTACGAACTAATTTTCCACCCCGACGCTGAAAGCGAAATTTATGAACTCGAGCCTGTTATGCAGGCAAAAGCTCTTAA
AGGACTTGAAAAGCTGGAAGCAAAAGGACCAGAGCTAAGGTATCCGGATACAGACATCATTGATGGTGGATTGTTCGAGT
TGCGAGTTGGTCGCAAAGACATAACCAGAACATTTTTTGCTTACGCCAAAGGACGCAGGATCTACATATTAAGAACGTTC
ATTAAGAAAACCCCTAAGACGCCAAAAGCTGAGATAGCGCTGGCTAAGTCAAGATGGGAGGAGTTGAAAGATGGCAGTTA
A

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT170472 WP_001288210.1 NZ_CP060504:1695579-1695836 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT170472 NZ_CP077405:192395-192679 [Citrobacter braakii]
ATGGCAGTTAAAGGCATCAGATTTTCAGAAATTAAAGCCAAAGCGCTTGCAAACCCTGAAGTCAAAAAGGCTTACGAGGA
AGAAACACAGGAAGAAGAGCTTCGCGCAGTCTTGGTCGAAATGAAATCCAAATCAGGGTTGACCAGCACAGAAATTGCTG
CTCGCATGGGTGTCAGTCAGCCAGCAGTAAGTCGACTTGAGAGAAACGTATCAAGTGCAAGCCTCTCAACTTTGCAGCGT
TACGCAGCTGCATGCGGAATGCACATTAAATTGTCTCTGAGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7