Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 839998..840851 Replicon chromosome
Accession NZ_CP060493
Organism Bifidobacterium longum strain BIM B-813D

Toxin (Protein)


Gene name relE Uniprot ID D6DCX6
Locus tag H8S96_RS03460 Protein ID WP_007056214.1
Coordinates 840360..840851 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A837U1I8
Locus tag H8S96_RS03455 Protein ID WP_007056210.1
Coordinates 839998..840360 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8S96_RS03450 837154..839853 + 2700 WP_013582802.1 aconitate hydratase AcnA -
H8S96_RS03455 839998..840360 + 363 WP_007056210.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H8S96_RS03460 840360..840851 + 492 WP_007056214.1 PIN domain-containing protein Toxin
H8S96_RS03465 840913..843018 - 2106 WP_013582801.1 DUF262 domain-containing protein -
H8S96_RS03470 843108..843749 - 642 WP_007052627.1 GNAT family N-acetyltransferase -
H8S96_RS03475 843789..844514 - 726 WP_007056206.1 response regulator transcription factor -
H8S96_RS03480 844549..845781 - 1233 WP_007056207.1 sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 757636..899324 141688


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-61)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18331.82 Da        Isoelectric Point: 4.5580

>T170470 WP_007056214.1 NZ_CP060493:840360-840851 [Bifidobacterium longum]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAESVMELGAKNNVTLLCASLSLKDIAYLSSSAIRREFKSNESEVENFTRSF
LSSRVPWHCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Download         Length: 492 bp

>T170470 NZ_CP077404:c1978284-1978006 [Streptococcus mutans]
ATGTACCAAGTCAAGTTCACCTCTGCTTTTAAAAAGAGCTACAAACGGATTAAAAAGCGAGGCTTAGAGATGACACTCTT
AGATGAAGTGATTGAAAAACTCCGCCTAGGACAGACACTAGAAGAAAAATACCGTGACCATGAACTCAAAGGAAACTTTG
TTGGCTTTAGGGAATGCCACATCAAGCCAGATTGGCTCTTGATTTATCTGATTGAAGATGATATTTTGACATTGACTTTA
GCTGATACAGGCAGTCATGCGGATTTGTTTAAGATGTGA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13944.04 Da        Isoelectric Point: 5.3491

>AT170470 WP_007056210.1 NZ_CP060493:839998-840360 [Bifidobacterium longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREAEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDAYYNMKRVD

Download         Length: 363 bp

>AT170470 NZ_CP077404:c1978557-1978285 [Streptococcus mutans]
ATGGCAACTGTTCCAACGCAAATTCGGATTGATGAAACTGTCAAAGCCCAAGCAACTTCATTATTTAATGACTTGGGGAT
GGATATGTCTAGTGCGGTCAATATTTTTCTTCGTCAATGTCTATTGCGTGGTGGACTTCCTTTCACGGTTGAAGTCCCCA
ATTATAGCCAAAAGACCTTAGAAGCTCTGGCAGAAGCTAAGCGTATTTCTCGTGATGAAACGGTCGCTTCTTATGGCAAT
CTAGCAGATTTAAAGAAGGCTCTGGAAGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837U113

Antitoxin

Source ID Structure
AlphaFold DB A0A837U1I8

References