170469

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2042583..2043060 Replicon chromosome
Accession NZ_CP060491
Organism Staphylococcus aureus strain WH39

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag H8N04_RS10235 Protein ID WP_000052078.1
Coordinates 2042872..2043060 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag H8N04_RS10230 Protein ID WP_001059690.1
Coordinates 2042583..2042843 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8N04_RS10195 2037976..2038692 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
H8N04_RS10200 2038840..2039262 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
H8N04_RS10205 2039661..2040155 + 495 WP_048665416.1 GNAT family N-acetyltransferase -
H8N04_RS10210 2040310..2040927 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
H8N04_RS10215 2041000..2041581 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
H8N04_RS10220 2041806..2042042 + 237 WP_000368687.1 hypothetical protein -
H8N04_RS10225 2042039..2042242 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
H8N04_RS10230 2042583..2042843 + 261 WP_001059690.1 hypothetical protein Antitoxin
H8N04_RS10235 2042872..2043060 + 189 WP_000052078.1 hypothetical protein Toxin
H8N04_RS10240 2043248..2043817 + 570 WP_001106654.1 hypothetical protein -
H8N04_RS10245 2043905..2044189 + 285 WP_001004395.1 hypothetical protein -
H8N04_RS10250 2044251..2044469 + 219 WP_000005886.1 hypothetical protein -
H8N04_RS10255 2044965..2045165 - 201 WP_001059082.1 cold-shock protein -
H8N04_RS10260 2045522..2046208 - 687 WP_001548082.1 thermonuclease family protein -
H8N04_RS10265 2046550..2047020 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T170469 WP_000052078.1 NZ_CP060491:2042872-2043060 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T170469 NZ_CP077404:c1974367-1974113 [Streptococcus mutans]
ATGTTTAACTTTACAGAACAAGCTTGGAAAGATTATGTTTCTTGGCAACAAGAAGATAAAAAGATACTCAAACGTATCAA
TCGTTTAATTGAGGATATCAAACGAAATCCTTTTGAAGGGATTGGAAAACCAGAGCCATTAAAATATCGTTATTCGGGTG
CTTGGTCTCGTAGAATTACAGATGAACACCGATTAGTCTATCTGGTTGAAGAAGATGAAATTTATTTCTTATCCTTTCGA
GACCATTATAAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT170469 WP_001059690.1 NZ_CP060491:2042583-2042843 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT170469 NZ_CP077404:c1974626-1974360 [Streptococcus mutans]
ATGGAAGCTGTAGTCTATTCAAATTTCAGAAACAACTTAAAGAATTATATGAAAAAAGTCAATGATGAATATGAACCTCT
AATGGTTGTCAATAAAAACCCTGATGAGAATATTGTGGTCTTATCTAAGGAAAACTGGGATAGTATTCAAGAAACCATCC
GCCTAATGAATAACGATTATCTTTCAGACAAGGTTCTATCAGGGATGGAACAAGTTAAACAAAAGAAAGTCGTTCAACGC
CAATTATTAGAGGTGGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References