Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 863016..863545 Replicon chromosome
Accession NZ_CP060491
Organism Staphylococcus aureus strain WH39

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag H8N04_RS04310 Protein ID WP_001103933.1
Coordinates 863228..863545 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag H8N04_RS04305 Protein ID WP_001058487.1
Coordinates 863016..863225 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8N04_RS04270 858247..858531 + 285 WP_000917289.1 co-chaperone GroES -
H8N04_RS04275 858607..860223 + 1617 WP_000240645.1 chaperonin GroEL -
H8N04_RS04280 860292..861464 - 1173 WP_000179353.1 site-specific integrase -
H8N04_RS04285 861478..862200 - 723 WP_000672427.1 helix-turn-helix domain-containing protein -
H8N04_RS04290 862353..862559 + 207 WP_000794657.1 helix-turn-helix transcriptional regulator -
H8N04_RS04295 862563..862880 + 318 WP_000481968.1 helix-turn-helix domain-containing protein -
H8N04_RS04300 862877..863023 + 147 WP_000708434.1 hypothetical protein -
H8N04_RS04305 863016..863225 + 210 WP_001058487.1 hypothetical protein Antitoxin
H8N04_RS04310 863228..863545 + 318 WP_001103933.1 DUF1474 family protein Toxin
H8N04_RS04315 863612..864481 + 870 WP_001002699.1 primase alpha helix C-terminal domain-containing protein -
H8N04_RS04320 864498..865967 + 1470 WP_001838755.1 virulence-associated E family protein -
H8N04_RS04325 866253..866615 + 363 WP_001039169.1 hypothetical protein -
H8N04_RS04330 866617..866901 + 285 WP_000998179.1 hypothetical protein -
H8N04_RS04335 866898..867539 + 642 WP_001019811.1 hypothetical protein -
H8N04_RS04340 868074..868415 + 342 WP_001190614.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 855372..885445 30073


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T170465 WP_001103933.1 NZ_CP060491:863228-863545 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T170465 NZ_CP077403:769526-769780 [Jonesia denitrificans]
GTGCGGCTGGTTTGGGACGAGGCCGCCTGGGAGGACTACAAGCACTGGCAGACGGCCGACCGGAGGGTCCTCAAGCGGAT
CAACCTGCTCATTGACGCCTGCCTGCGCGAGCCGTTCGAGGGCATTGGCAAGCCTGAGCAGCTGAAGTACGGCGTGCAGG
GCTCGTGGTCCCGGCGGATCAATGAGGAGCACAGGCTCGTCTATCTCGTCGACGGCGACGATCTCGTGATCCTGCAGGCC
CGCTACCACTACTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT170465 WP_001058487.1 NZ_CP060491:863016-863225 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT170465 NZ_CP077403:769247-769525 [Jonesia denitrificans]
ATGTCCATCAGCGCGAGCGAGGCCCGCAAGACGCTGTTTCCGCTCATCGAGCGCGTGAACCAGGATCACGAAGCTATCGA
GATCGTCTCCCGCAAGGGCAACGCGGTGCTCATGCCGGCCGACGAGTACGCCGCCTGGCAGGAGACCGCCTACCTGTTCC
GCTCGCCGGCGAACGCGCGCAGGCTGCTCGACGCCTACGACCGCGCCCGCGCCGGGAAGGTGCAGGCTCACGAACTCGAC
CGCTCCGACGAGCCCGCAGATCAGCCTCGGGGCATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References