Detailed information of TA system TA170464

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 809816..810345
• Replicon: chromosome
• Accession: NZ_CP060491
• Organism: Staphylococcus aureus strain WH39

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: H8N04_RS04030
• Protein ID: WP_000621175.1
• Coordinates: 809983..810345 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: H8N04_RS04025
• Protein ID: WP_000948331.1
• Coordinates: 809816..809986 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8N04_RS03995	804852..805412	+	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-
H8N04_RS04000	805621..806100	+	480	WP_001287088.1	hypothetical protein	-
H8N04_RS04005	806093..807676	+	1584	WP_001294626.1	PH domain-containing protein	-
H8N04_RS04010	807663..808154	+	492	WP_001205910.1	PH domain-containing protein	-
H8N04_RS04015	808158..808517	+	360	WP_000581200.1	holo-ACP synthase	-
H8N04_RS04020	808583..809731	+	1149	WP_001281145.1	alanine racemase	-
H8N04_RS04025	809816..809986	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
H8N04_RS04030	809983..810345	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
H8N04_RS04035	810695..811696	+	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
H8N04_RS04040	811815..812141	+	327	WP_001052491.1	anti-sigma factor antagonist	-
H8N04_RS04045	812143..812622	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
H8N04_RS04050	812597..813367	+	771	WP_001041103.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T170464 WP_000621175.1 NZ_CP060491:809983-810345 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T170464 NZ_CP077399:1927887-1928540 [Aeromonas sp. FDAARGOS 1407]
ATGGCCTATGACTATAGCCAGAGCCTGAATCCGCAGAAGGCGCTGATATTCCGGATCGTGCATCGGGATAACCTGGAGTG
GATCCTGACCCATGGCCTGTGGGCGGGAAATGGTCAGCAGCAAAACCCGCACTGGGTGCATATCGGGCTGCCGGAGCTGA
TTGCCAAGCGCGCGCGCCATCCGGTGCCGCTGGCGCCTTACGGCGTGTTGAATGACTATGTGCCCTTCTATTTCACGCCG
TTTTCTCCCATGCTCAGCAATATTCACTCGGGGCGCGGTGTTCCCCAGCGTGACAATGATGAAATCCTGATCCTGGTTTC
CAGCCTGCATCGCATGGCTGAATTGGGGCTACCGTTTGTGTTTACCGATAGCCATGCCTATTACCAGTGGGCCAATTTCT
ATGTCGACCTTGGCGATCTGGGGCGGATTGACTGGCCACTGTTGCAGCGCCGTGATTTCAAGCGTGATGCGGACGATTTG
AGCAAGCTGGAGCGCTATCAGGCCGAGGCCTTGATCCATCAACATTGCCCCATCGAGGCGTTGCTGGGCGTGGTGTGTTA
CAACGAAGAAATAAAGAACCGCGTGGAACAATGCATGAATCGGGTCGGGGTCGCGCGCCCCGTCTATGTCCGTGATGGGT
GGTATTTCAGATGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT170464 WP_000948331.1 NZ_CP060491:809816-809986 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT170464 NZ_CP077399:1928537-1929601 [Aeromonas sp. FDAARGOS 1407]
ATGATTCGATATACAACAGGCAATCTGCTGGATGCTCCGGTGGAAGCGCTGGTGAATACCGTCAACACCGTCGGTGTCAT
GGGCAAGGGGATCGCCTTGATGTTCAAAGAGCGGTTCCCGGCCAATATGCGCGCCTATGCCGAGGCGTGCAAACAGGGTG
ATGTCGTCACCGGCAAGATGTTTATTACCCAGACGGGTGAGCTGCTGGGGCCGCGCTGGATCGTGAATTTTCCGACCAAA
CAGCATTGGCGCAATCCGGCACAGATGGCGTGGATCCAGGATGGTTTGCAGGATCTGCGGGCCTGGTTACAGGCGCAGCA
GGTCTCTTCGATTGCCATTCCACCACTGGGGGCTGGCAACGGCGGTCTGCCTTGGCCGGAGGTCAAACAGGCGATCGAAA
CGGCACTGGGCGATCTGGATATCGATATCCTGCTCTATGAGCCCAGTCACCAATACCAAAATGTGGCCAAGCGCGGCGGG
GTGGCGGAGCTGACTCCGGCTCGAGCCTTGATTGCTGAACTGGTGCGCCGCTACTGGTTTTTAGGGATGGAGTGCAGCTT
GCTGGAGATCCAGAAACTGGCCTGGTTTCTGGCTCGGGTCATTGGCCGTAACCCGATGGGGGATCCGCTGCAGTTGCAGT
TTAAGGCCCATCGTTATGGCCCTTATGCCAACAATCTGACCCATCTGCTCAATGCGATGGACGGCAGTTATCTGCAGTCC
GACAAGCGCATCCCGGATAGCAAGCCGTTTGATGTCATCTGGTTTAATGAGGCTAAAAAACAAGAGCTTGCCGTTTATCT
CAATACCGAGGCCAAAGCATTTTTACCGATACTGGAGCAGACGACCGCGTTAATCGATGGTTTTGAGTCGCCCTATGGCA
TGGAGTTATTGGCCACGGTGGACTGGCTGATGGTCGAAGAGGGCTGTGCGCCGACACTGAGCGCGCTGCGCGAGGGGTTG
CACCGCTGGCCAGCGGGAACCCCGTGGGGTGATCGCAAGGCGCGGCTGTTTGATGATCGCAGCCTGCAGATCGCCTTGAC
CCGTTTGCAGCAGGGATTGGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1