Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 788237..788751 Replicon chromosome
Accession NZ_CP060491
Organism Staphylococcus aureus strain WH39

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag H8N04_RS03930 Protein ID WP_000581792.1
Coordinates 788542..788751 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag H8N04_RS03925 Protein ID WP_000138932.1
Coordinates 788237..788530 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8N04_RS03905 783600..784241 + 642 WP_000483153.1 thiamine phosphate synthase -
H8N04_RS03910 784327..785199 + 873 WP_000725802.1 membrane protein insertase YidC -
H8N04_RS03915 785912..786559 - 648 WP_001187629.1 HD domain-containing protein -
H8N04_RS03920 786587..788071 - 1485 WP_000571549.1 cardiolipin synthase -
H8N04_RS03925 788237..788530 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
H8N04_RS03930 788542..788751 + 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
H8N04_RS03935 788879..789016 + 138 WP_000828354.1 hypothetical protein -
H8N04_RS03940 789280..790482 - 1203 WP_001109939.1 rod shape-determining protein RodA -
H8N04_RS03945 790800..791870 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
H8N04_RS03950 791885..793243 + 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T170463 WP_000581792.1 NZ_CP060491:788542-788751 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T170463 NZ_CP077398:3814622-3815011 [Acinetobacter nosocomialis]
TTGACCAACCATTTGAATTTCAAACTGAAATATAGCCGTTTTGCGATTATATTTCAGTTTTTTATTGGCTTAAGTTTGGC
AGTTCTATTTTATCAACTCCTACCAATACTATGGTGGTTGGTTACGGTCAGTTTACTATTCATAAGTTTTATTTTCTTTT
TAAAGCGGCCACAGCTCGCTCAAATTGCTCATTTAGATCAAAAATTATGGTCACTTAGCTTTCATTCAGAACAAACAATT
TCTCGGGTAGAGATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTGAAGGGCGTAAGACATTAACTTC
TGTTATTTGGTTTGATCAAATGCCTCTATCTCACTGGAAACAACTTAAAACCTTAGAAAAATTTTATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT170463 WP_000138932.1 NZ_CP060491:788237-788530 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT170463 NZ_CP077398:3814358-3814615 [Acinetobacter nosocomialis]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTT
TGACCCGTATGTGAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAG
ATCCTGATTTACTTGATTGGTTTATGGAAGTATCTGAACCGCCACGTACAGAGTTACGTGATTTTATCCATAAATTAAAG
CATTATGTTCATGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References