Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5154617..5155284 Replicon chromosome
Accession NZ_CP060470
Organism Xanthomonas citri pv. citri strain DAR73889

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag H8Z72_RS22175 Protein ID WP_005916679.1
Coordinates 5154868..5155284 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag H8Z72_RS22170 Protein ID WP_005916676.1
Coordinates 5154617..5154871 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8Z72_RS22145 5150727..5150946 + 220 Protein_4329 RNA 2'-phosphotransferase -
H8Z72_RS22150 5151115..5152380 + 1266 WP_040280600.1 cardiolipin synthase B -
H8Z72_RS22155 5152406..5152933 - 528 WP_005916668.1 hypothetical protein -
H8Z72_RS22160 5153172..5153378 + 207 WP_003489327.1 hypothetical protein -
H8Z72_RS22165 5153365..5154471 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
H8Z72_RS22170 5154617..5154871 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
H8Z72_RS22175 5154868..5155284 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
H8Z72_RS22180 5155406..5155618 - 213 WP_015472900.1 hypothetical protein -
H8Z72_RS22185 5155737..5155949 - 213 WP_203197330.1 hypothetical protein -
H8Z72_RS22190 5156206..5157825 + 1620 WP_015463800.1 hypothetical protein -
H8Z72_RS22195 5157929..5158327 - 399 WP_004429277.1 DUF2384 domain-containing protein -
H8Z72_RS22200 5158643..5159074 + 432 WP_005922907.1 hypothetical protein -
H8Z72_RS22205 5159103..5159429 - 327 Protein_4341 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T170451 WP_005916679.1 NZ_CP060470:5154868-5155284 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T170451 NZ_CP077388:2918016-2918753 [Providencia rettgeri]
GTGACTTTATTCGCTCAAGTACTGGGGCTCATCAGTTTAAATGATGTGCCCCATAGTTTTATTTTAAATGTAGGTGAAAT
AAAGGCGTTAGCGGTTGAACGTTTTGAGCGTAAATATTCTTCTGATTCCTCGTGGATTATGCGTTTACCACAAGAAGATT
TTTGTCAAACATTGAATATTTCACCGGCAAGAAAATATCAAAATCATGGTGGACCGGGTATTTCTGAAATTATGAATTAC
TTATTAGGTTCAATAAATGCAGAGAAAGATAGATATCAGTTTATGAAGAGCCAGGTTTTGTTTTGGTTACTTGCAGCGAC
GGATGGCCATGCTAAAAATTTTTCATTATTTATTGAACCTGAAGGCCGTTATCAGTTAACACCTTTTTACGATATTTTGT
CCATGTATCCTAGTTATGGGGGGAGGGGAATTAACCCTAGAGATGCCAAATTGGCTATGGGGCTGAAGGGAACAAGGGAG
ATGAAATACAATATAGAGCAAATTTTTCCAAGGCATTTTTTTGCAACGGCCAAGGAGGTTGGTTTTGACCGCACTGAAAT
GGAAAAAATCTTAATTGAGTTTGATGAGCAAATGGAAAGTGTTATTACAAAGGTTAGGGAACAGCTTCCAACCAATTTCC
CTAAGCACATTGCAGACTCAATTTTATCAGGGTTACATCATAAAGCCGCACGATTAAAAAAAGTTGGGATTAATCCTTTA
CCCGACTCGGATGGGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT170451 WP_005916676.1 NZ_CP060470:5154617-5154871 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT170451 NZ_CP077388:2917707-2917976 [Providencia rettgeri]
ATGAAAGTGACCAATACCCGACAACTTAGTGCTTACATGAAAGATGTCAGAGAGACGAAAAAATTATCTCAAAGTAAAGT
CGCAAGTAAAGTGGGTATTCGGCAAGATACCGTCTCCAGTTTTGAACTCTCTCCTGACTCTACCAAATTAGAAACCTTCT
TTAAGATTTTATCTGCCCTAAATTTAGAACTCGATATTAAACCGCGAAATGAAAGTGGCTCATCAAACTCAAACTCAAAT
TCAAACTCTGGATGGAAGGAGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References